455957-73-0

Basic information

• Product Name: 3-Pyrrolidinecarboxylic acid, 4-(2,4-difluorophenyl)-1-(1,1-dimethylethyl)-, methyl ester, (3S,4R)-
• Synonyms: 3-Pyrrolidinecarboxylic acid, 4-(2,4-difluorophenyl)-1-(1,1-dimethylethyl)-, methyl ester, (3S,4R)-
• CAS NO: 455957-73-0
• Molecular Formula: C₁₆H₂₁F₂NO₂
• Molecular Weight: 297.3402464
• Mol File: 455957-73-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 320.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.160±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.52±0.60(Predicted)
• CAS DataBase Reference: 3-Pyrrolidinecarboxylic acid, 4-(2,4-difluorophenyl)-1-(1,1-dimethylethyl)-, methyl ester, (3S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyrrolidinecarboxylic acid, 4-(2,4-difluorophenyl)-1-(1,1-dimethylethyl)-, methyl ester, (3S,4R)-(455957-73-0)
• EPA Substance Registry System: 3-Pyrrolidinecarboxylic acid, 4-(2,4-difluorophenyl)-1-(1,1-dimethylethyl)-, methyl ester, (3S,4R)-(455957-73-0)

Safety Data

• Hazardous Substances Data: 455957-73-0(Hazardous Substances Data)

Upstream product

• 455954-96-8 N-(methoxymethyl)-2-methyl-N-[(trimethylsilyl)methyl]propane-2-amine 
• 186758-21-4 methyl (2E)-3-(2,4-difluorophenyl)prop-2-enoate 
• 862283-30-5 PF-884918 
• 616-38-6 carbonic acid dimethyl ester 
• 79250-80-9 N-tert-butyl<(trimethylsilyl)metyl>amine 
• 455957-94-5 (3S,4R)-N-tert-butyl-4-(2,4-difluoro-phenyl)-pyrrolidine-3-carboxylic acid 
• 67-56-1 methanol 

Downstream Products

• 455957-94-5 (3S,4R)-N-tert-butyl-4-(2,4-difluoro-phenyl)-pyrrolidine-3-carboxylic acid 
• 923948-65-6 (3S,4R)-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylic acid methyl ester 

Relevant articles and documents

Pharmaceutical compositions (by machine translation)

[Problem] imidazole compound or its pharmacologically acceptable salt in the melanocortin receptor activity that operates as an active ingredient of a pharmaceutical composition comprising. "I" general formula [a]" Formula, the aryl group may be substituted A ring represents a; R1 Represents a hydrogen atom, or an alkyl group which may be substituted represented; R2 Represents a hydrogen atom, a halogen atom or represents a; R3 The alkyl group may be substituted " represented by the imidazole compound, its pharmacologically acceptable salt as an active ingredient in a pharmaceutical composition. [Drawing] no (by machine translation)

Pharmaceutically active compounds

The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) wherein R1, R2, R3, R4 and R5 are as defined herein and especially to selective MCR4 agonist compounds, to

BICYCLIC PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS

Certain novel bicyclic N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or p