4568-88-1

Basic information

• Product Name: 4-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-7-yl N-(tert-butoxycarbonyl)tryptophanate
• CAS NO: 4568-88-1
• Molecular Formula: C₁₇H₃₄O₄
• Molecular Weight: 568.6164
• Mol File: 4568-88-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 789.4°C at 760 mmHg
• Flash Point: 431.2°C
• Density: 1.286g/cm³
• Vapor Pressure: 6.77E-25mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: 4-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-7-yl N-(tert-butoxycarbonyl)tryptophanate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-7-yl N-(tert-butoxycarbonyl)tryptophanate(4568-88-1)
• EPA Substance Registry System: 4-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-7-yl N-(tert-butoxycarbonyl)tryptophanate(4568-88-1)

Safety Data

• Hazardous Substances Data: 4568-88-1(Hazardous Substances Data)

Upstream product

• 488117-69-7 (S)-14-(2,2-dimethyl-[1,3]dioxolan-4-yl)-tetradecanoic acid methyl ester 
• 7735-38-8 13-hydroxytridecanoic acid 
• 112-86-7 cis-13-docosenoic acid 
• 15462-16-5 13-bromotridecanoic acid 
• 65157-88-2 13-oxotridecanoic acid 
• 80982-86-1 methyl ω-bromotridecanoate 
• 488117-68-6 (E)-14-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-tetradec-13-enoic acid methyl ester 
• 7147-29-7 methyl ω-hydroxytridecanoate 

Downstream Products

• 945226-22-2 C₄₇H₈₉N₃O₈ 
• 4617-33-8 15-hydroxylpentadecanoic acid 
• 76529-42-5 methyl 15-hydroxypentadecanoate 
• 18270-60-5 15-hydroxy-pentadecanoic acid hydrazide 

Relevant articles and documents

Annonaceous acetogenin mimics bearing a terminal lactam and their cytotoxicity against cancer cells

Annonaceous acetogenins are a large class of naturally occurring polyketides exhibiting potent anticancer activities. Based on our previous discovery of AA005, a multi-ether mimic of natural acetogenins having potent antitumor activities and significant selectivity between normal cells and cancer cells, a new series of mimics containing a terminal lactam were designed, synthesized and evaluated. Bioactivity study against cancer cells shows that the N-methylated lactam-containing compounds 3, 4, and 5 exhibit comparable potencies to that of AA005, as well as the similar selectivity to cancer cells. Hydrocarbon-length effects of N-alkyl were further explored through synthesizing derivatives 24-26, and application of this derivation protocol to the fluorescent labeling was also investigated.

Enantiopure simple analogues of annonaceous acetogenins with remarkable selective cytotoxicity towards tumor cell lines

Structure simplification with conservation of the essential functionalities for biological activity has been achieved with the design and synthesis of four analogues of annonaceous acetogenins. The compounds ((15 R/S, 24 R/S)-1) are easily synthesized wit