4569-98-6

Basic information

• Product Name: 7-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one
• Synonyms: 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-; 7-Hydroxy-3-(4-hydroxyphenyl)-5-methoxy-4H-1-benzopyran-4-one
• CAS NO: 4569-98-6
• Molecular Formula: C₁₆H₁₂O₅
• Molecular Weight: 284.2635
• Mol File: 4569-98-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 567.9°C at 760 mmHg
• Flash Point: 218.3°C
• Density: 1.42g/cm³
• Vapor Pressure: 1.68E-13mmHg at 25°C
• Refractive Index: 1.668
• Storage Temp.: ?20°C
• CAS DataBase Reference: 7-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one(4569-98-6)
• EPA Substance Registry System: 7-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one(4569-98-6)

Safety Data

• Hazard Codes: T,N
• Statements: 25-50
• Safety Statements: 45-61
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 4569-98-6(Hazardous Substances Data)

Usage

General Description

7-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one, also known as isofraxidin, is a naturally occurring chemical compound found in plants such as Angelica and Oenanthe. It belongs to the class of flavonoids and is known for its antioxidant, anti-inflammatory, and neuroprotective properties. Research has shown that isofraxidin has potential therapeutic effects in the treatment of various diseases, including cardiovascular disorders, cancer, and neurodegenerative diseases. Its antioxidant properties make it valuable in protecting cells from damage caused by free radicals, and its anti-inflammatory effects may help reduce inflammation and pain. This chemical compound has also shown potential as a drug candidate for certain types of cancer and other health conditions.

Upstream product

• 853925-90-3 7-hydroxy-3-(4-hydroxy-phenyl)-5-methoxy-4-oxo-4H-chromene-2-carboxylic acid 
• 100409-92-5 5-O-methylgenistein diacetate 
• 872787-38-7 7-benzyloxy-3-(4-benzyloxy-phenyl)-5-methoxy-chromen-4-one 
• 119692-04-5 4'-benzyloxy-7-hydroxy-5-methoxyisoflavone 
• 5995-97-1 4',5,7-Triacetoxyisoflavone 
• 643761-16-4 7-benzyloxy-3-(4-benzyloxy-phenyl)-5-hydroxy-chromen-4-one 
• 2174-64-3 5-methoxyresorcinol 
• 14191-95-8 4-cyanomethylphenol 
• 56308-11-3 2,4,4'-trihydroxy-6-methoxy-deoxybenzoin 
• 853925-89-0 7-hydroxy-3-(4-hydroxy-phenyl)-5-methoxy-4-oxo-4H-chromene-2-carboxylic acid ethyl ester 
• 128856-77-9 5-O-methylgenistein-7-O-β-D-glucopyranoside 

Downstream Products

• 100409-92-5 5-O-methylgenistein diacetate 
• 1162-82-9 4',5,7-trimethoxyisoflavone 

Relevant articles and documents

A new approach towards acid catalysts with high reactivity based on graphene nanosheets

Solid acid catalysts of graphene oxide and sulfonated graphene oxide nanosheets have been prepared by using the modified Hummers and sulfonation methods. Physical characterization indicated that a number of functional groups such as -COOH, -OH, -O-, and -SO3H were introduced onto the surfaces of the as-synthesized nanosheets. The catalytic performance of the synthesized catalysts was evaluated in the hydrolysis of the glycosidic bond and Fischer esterification. The experimental results indicated that the catalytic activity of the sulfonated graphene oxide was superior to that of other solid acid catalysts with the same or higher acid strength and has also exceeded that of H2SO4 with 9.1 times of acid strength than that of the sulfonated graphene oxide. The high reactivity can be ascribed to the formation of hydrophobic cavities through the combination of graphene sheet and the oxygen-containing groups on its surface, which may facilitate the catalyst to anchor with reactants and promote the attack of protons.

Studies on Zoospore-Attracting Activity. I. Synthesis of Isoflavones and Their Attracting Activity to Aphanomyces euteiches Zoospore

Prunetin (2) and its derivatives were synthesized in order to study the relationship between structure and attracting activity to Aphanomyces euteiches zoospore.All of the derivatives (1, 2, 4 and 6), which had a hydroxyl group at the C-5 position in the isoflavone, showed attracting activity, but the methyl ether derivatives (3, 5, 7 and 8) do not have or have very weak attracting activity.The isoflavones (1, 2, and 4) with strong attracting activity also had estrogenic activity.Keywords - isoflavone; prunetin; genistein; biochanin A; 5-methylgenistein; 5-hydroxy-4',7-dimethoxyisoflavone; Aphanomyces euteiches; zoospore; attracting activity; estrogenic activity