457074-41-8Relevant articles and documents
A practical approach to the synthesis of 2,4-disubstituted oxazoles from amino acids
Morwick, Tina,Hrapchak, Matt,DeTuri, Molly,Campbell, Scot
, p. 2665 - 2668 (2007/10/03)
(Matrix presented) A new sequence for the synthesis of various 2,4-disubstituted oxazoles from α-amino acids is reported. The method is shown to be general and incorporates the reagent combination, triphenylphosphine/hexachloroethane, for cyclodehydration of intermediate α-acylamino aldehydes. Implementation of this reagent system for the conversion of α-acylamino ketones to oxazoles is briefly investigated.