457606-27-8Relevant articles and documents
Synthesis of ketone analogues of prolyl and pipecolyl ester FKBP12 ligands
Wu, Yong-Qian,Wilkinson, Douglas E.,Limburg, David,Li, Jia-He,Sauer, Hansjorg,Ross, Doug,Liang, Shi,Spicer, Dawn,Valentine, Heather,Fuller, Mike,Guo, Hong,Howorth, Pam,Soni, Raj,Chen, Yi,Steiner, Joseph P.,Hamilton, Gregory S.
, p. 3558 - 3568 (2007/10/03)
The recently discovered small-molecule ligands for the peptidyl and prolyl isomerases (PPIase) of FKBP12 have been shown to possess powerful neuroprotective and neuroregenerative effects. Ketone analogues of the prolyl and pipecolyl esters, which mimic on