457613-78-4

Basic information

• Product Name: (4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]PHENYL)BORONIC ACID
• Synonyms: (4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]PHENYL)BORONIC ACID;4-(4-BOC-Piperazino)phenylboronic acid;1-Piperazinecarboxylic acid, 4-(4-boronophenyl)-, 1-(1,1-diMethylethyl) ester;[4-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]phenyl]boronic acid
• CAS NO: 457613-78-4
• Molecular Formula: C₁₅H₂₃BN₂O₄
• Molecular Weight: 306.17
• Product Categories: Boronate Ester;Boronic Acid;Potassium Trifluoroborate
• Mol File: 457613-78-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: 187-189 °C
• Boiling Point: 487.4±55.0 °C(Predicted)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: 9.08±0.17(Predicted)
• CAS DataBase Reference: (4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]PHENYL)BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]PHENYL)BORONIC ACID(457613-78-4)
• EPA Substance Registry System: (4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]PHENYL)BORONIC ACID(457613-78-4)

Safety Data

• Hazardous Substances Data: 457613-78-4(Hazardous Substances Data)

Usage

Description

(4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]PHENYL)BORONIC ACID, also known as 4-(4-BOC-Piperazino)phenylboronic acid, is a chemical compound with a complex structure that features a boron atom bonded to a phenyl group and a piperazinyl group. (4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]PHENYL)BORONIC ACID is characterized by its reactivity and ability to form stable intermediates, making it a valuable building block in organic synthesis.

Uses

Used in Pharmaceutical Industry:
(4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]PHENYL)BORONIC ACID is used as a reagent for the synthesis of hydroxyaniline amides, which are selective extracellular regulated Kinase (Erk) inhibitors. These inhibitors play a crucial role in the development of drugs targeting various diseases, including cancer and inflammatory conditions, by modulating the Erk signaling pathway.
Used in Organic Synthesis:
(4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]PHENYL)BORONIC ACID is used as a key intermediate in the preparation of 3,5-disubstituted indole derivatives. These derivatives have been identified as potent inhibitors of pim-1, pim-2, and pim-3 protein kinases. The inhibition of these kinases has potential therapeutic applications in the treatment of various diseases, including cancer, by targeting the cell cycle and apoptosis pathways.

Upstream product

• 352437-09-3 tert-butyl 4-(4-bromophenyl)piperazine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5419-55-6 Triisopropyl borate 
• 151978-66-4 tert-butyl 4-(4-iodophenyl)tetrahydro-1(2H)-pyrazinecarboxylate 
• 121-43-7 Trimethyl borate 

Downstream Products

• 459164-54-6 4-{4'-[1-(cyanomethyl-carbamoyl)-3-methyl-butylamino]-biphenyl-4-yl}-piperazine-1-carboxylic acid tert-butyl ester 
• 756870-01-6 4-(4-{4-[1-(cyanomethyl-carbamoyl)-3-methyl-butylamino]-thiophen-3-yl}-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 513246-99-6 (4-(piperazin-1-yl)phenyl)boronic acid 
• 942189-35-7 4-(4-pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 1064623-19-3 methyl (3R,6S,8R)-8-{4'-[4-(tert-butoxycarbonyl)piperazin-1-yl]biphenyl-4-yl}-6-(2-fluoro-2-methylpropyl)-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yne-3-carboxylate 
• 1163177-03-4 C₂₁H₂₄N₂O₂S₄ 
• 1202880-76-9 tert-butyl 4-(4-(pyridin-4-yl)phenyl)piperazine-1-carboxylate 
• 1312579-40-0 3-[4-chloro-1-methyl-2-(4-piperazin-1-yl-phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-N-(2-dimethylamino-ethyl)-benzamide 
• 1312581-11-5 4-[4-(4-chloro-3-iodo-1-methyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1312581-10-4 4-[4-(4-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1312581-15-9 4-[4-(4-chloro-1-methoxymethyl-7-azaindole)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1605327-72-7 (S)-tert-butyl 4-(4-(4-amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)phenyl)piperazine-1-carboxylate 
• 1605327-82-9 (S)-2-(1-((6-amino-5-(4-(piperazin-1-yl)phenyl)pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one 

Relevant articles and documents

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