457639-26-8 Usage
Description
2,5-DiMethyl Celecoxib, also known as 2,5-di-Me celecoxib (DMC), is a non-cyclooxygenase-2 (COX-2) inhibitor analog of Celecoxib (C251000). It lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib.
Used in Pharmaceutical Industry:
2,5-DiMethyl Celecoxib is used as a cytotoxic agent for its comparable cytotoxic properties to Celecoxib, despite not inhibiting COX-2.
Used in Research Applications:
2,5-DiMethyl Celecoxib is used as a research tool to block the synthesis of prostaglandin E2 and to study the effect of transforming growth factor-2 signaling towards cyclooxygenase-2 expression.
Used in Cancer Research:
In an in vitro study, 2,5-DiMethyl Celecoxib is used to analyze its pro-oxidative capacities in metastatic melanoma/breast cancer cells, providing insights into its potential role in cancer treatment.
Used in Pharmaceutical Research for Osteoarthritis:
2,5-DiMethyl Celecoxib is used in studies to investigate its interaction with silymarin on chemically induced osteoarthritis in rats, contributing to the understanding of its potential therapeutic effects in treating osteoarthritis.
Biochem/physiol Actions
Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.
Check Digit Verification of cas no
The CAS Registry Mumber 457639-26-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,7,6,3 and 9 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 457639-26:
(8*4)+(7*5)+(6*7)+(5*6)+(4*3)+(3*9)+(2*2)+(1*6)=188
188 % 10 = 8
So 457639-26-8 is a valid CAS Registry Number.
457639-26-8Relevant articles and documents
1,5-diarylpyrazole derivative, and synthetic method and application thereof
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Paragraph 0039; 0041; 0044; 0053-0054, (2021/07/01)
The invention relates to a 1,5-diaryl pyrazole derivative and antibacterial application thereof. On the basis of a celecoxib structure, structural modification is conducted on 1,5-diaryl to obtain the 1,5-diaryl pyrazole derivative; and after structural c
