457907-91-4

Basic information

• Product Name: 2-(2-dodecanoylamino-benzoylamino)-benzoic acid
• Synonyms: 2-(2-dodecanoylamino-benzoylamino)-benzoic acid
• CAS NO: 457907-91-4
• Molecular Weight: 438.567
• Mol File: 457907-91-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-dodecanoylamino-benzoylamino)-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-dodecanoylamino-benzoylamino)-benzoic acid(457907-91-4)
• EPA Substance Registry System: 2-(2-dodecanoylamino-benzoylamino)-benzoic acid(457907-91-4)

Safety Data

• Hazardous Substances Data: 457907-91-4(Hazardous Substances Data)

Upstream product

• 112-16-3 n-dodecanoyl chloride 
• 612-34-0 N-anthraniloyl-anthranilic acid 
• 118-92-3 anthranilic acid 
• 118-48-9 isatoic anhydride 

Relevant articles and documents

An efficient, convenient synthesis of novel medium-sized 13H-dibenzo[d,h][1,3,7]oxadiazecine-8,14-dione macrolides as anticipated antineoplastic agents

A series of novel medium-sized 13H-dibenzo[d,h][1,3,7]oxadiazecine-8,14-dione macrolides (18-27, 30, 32) were synthesized in an ongoing effort to develop new antineoplastic agents. The synthon 2-(2-aminobenzoylamino)-benzoic acid (7), for preparation of the target compounds, was prepared via the reaction of isatoic anhydride 5 and anthranilic acid 6. Nine compounds (18-20, 24-27, 30, 32) were subjected to National Cancer Institute (NCI) in vitro disease-oriented human cells screening panel assay. Among the compounds tested, 6-benzyl-13H-dibenzo[d,h][1,3,7]oxadiazecine-8,14-dione (26, NSC 721327), bearing the benzyl group at position 6, showed cytotoxic activity and subpanel selectivity against leukemia (CCRF-CEM), colon (HCC-2998), CNS (SNB-75) and melanoma (UACC-257) panels at log10 GI50 (M), compound concentration that inhibits 50% of cell growth, ranging from -4.08 to -4.59.