45891-14-3Relevant articles and documents
Synthesis of 4-Organoselanyl-1H-pyrazoles: Oxone -Mediated Electrophilic Cyclization of α,β-Alkynyl Hydrazones by Using Diorganyl Diselenides
Perin, Gelson,Nobre, Patrick C.,Mailahn, Daniela H.,Silva, Márcio S.,Barcellos, Thiago,Jacob, Raquel G.,Lenard?o, Eder J.,Santi, Claudio,Roehrs, Juliano A.
, p. 2293 - 2304 (2019/05/24)
A simple and efficient method for the synthesis of 4organoselanyl-1 H -pyrazoles has been developed, taking place under metal- and halogen-free conditions. Electrophilic species of selenium were easily generated in situ by the reaction of diorganyl diselenides with Oxone in ethanol as solvent in an open-flask at 70 °C. These electrophilic selenium species were employed in the selenylation/cyclization of α,β-alkynyl hydrazones, giving the title compounds in moderate to excellent yields. The final species of selenium obtained from the reaction of diphenyl diselenide with Oxone were characterized by 77 Se NMR spectroscopy and high-resolution mass spectrometry (HRMS).
