459157-64-3

Basic information

• Product Name: 2-cyano-3-[2-(indol-3-yl)ethyl]-4(3H)-quinazolin-4-one
• Synonyms: 2-cyano-3-[2-(indol-3-yl)ethyl]-4(3H)-quinazolin-4-one
• CAS NO: 459157-64-3
• Molecular Weight: 314.346
• Mol File: 459157-64-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-cyano-3-[2-(indol-3-yl)ethyl]-4(3H)-quinazolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyano-3-[2-(indol-3-yl)ethyl]-4(3H)-quinazolin-4-one(459157-64-3)
• EPA Substance Registry System: 2-cyano-3-[2-(indol-3-yl)ethyl]-4(3H)-quinazolin-4-one(459157-64-3)

Safety Data

• Hazardous Substances Data: 459157-64-3(Hazardous Substances Data)

Upstream product

• 61-54-1 tryptamine 
• 853995-64-9 methyl N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-anthranilate 

Downstream Products

• 84-26-4 rutaecarpine 

Relevant articles and documents

A short synthesis of quinazolinocarboline alkaloids rutaecarpine, hortiacine, euxylophoricine A and euxylophoricine D from methyl N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)anthranilates

Reactions of methyl N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)anthranilates with tryptamine at room temperature produced 2-cyano-3-[2-(indol-3-yl)ethyl]-4(3H)-quinazolinones, which underwent cyclization on heating with TFAA/HCl(g) to afford quinazolinocarboline alkaloids rutaecarpine (1a), hortiacine (1b), euxylophoricine A (1c) and euxylophoricine D (1d) in excellent yields.