459410-39-0Relevant articles and documents
Synthesis of N-(2-chloro-3,4-dimethoxybenzylideneamino)guanidinium acetate [α-14C]
Almeida, Maria,Boman, Arne,Lundstedt, Torbjrn
, p. 371 - 377 (2002)
14C-Labelled N-(2-chloro-3,4-dimethoxybenzylideneamino)guanidinium acetate has been synthesized as a part of a four-step procedure which involved decarboxylation of 2-chloro-3,4-dimethoxybenzoic acid by Pb(OAc)4 to give 2-chloro-3,4-dimethoxy-1-iodobenzene, followed by a selective lithiation at the iodine position and electrophilic substitution with N,N-dimethylformamide [α-14C] and final reaction with aminoguanidine bicarbonate. The specific activity was 59 mCi/mmol and the overall yield 49%. Copyright