459434-40-3Relevant articles and documents
N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]
Liu, Peng,Tung, Nguyen Thanh,Xu, Xiangchao,Yang, Jiazhi,Li, Feng
, p. 2621 - 2631 (2021/02/27)
A ruthenium complex [(p-cymene)Ru(2,2′-bpyO)(H2O)] was found to be a general and efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate salt. Moreover, a series of sensitive substituents, such as nitro, ester, cyano, and vinyl groups, were tolerated under present conditions. It was confirmed that OH units in the ligand are crucial for the catalytic activity. Notably, this research exhibited the potential of metal-ligand bifunctional ruthenium catalysts for the hydrogen autotransfer process.
Method for preparing TNNI3K inhibitor (by machine translation)
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, (2020/03/12)
The method TNNI3K comprises the following steps: heating the m-bromobenzene sulfonamide in the presence of an iridium complex catalyst and a base: for a few hours and then cooling to room temperature, to dry the solvent, to obtain, methyl - 3 3-aminobenze
Synthetic TNNI3K inhibitors (by machine translation)
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, (2019/03/26)
The invention discloses a method for synthesizing TNNI3K inhibitors, proceeding from interval tetrabromobensoate sulfonamides, containing double-imidazole ligand iridium complex and under the action of the weak catalytic activation methanol instead of high toxicity halogenated methane get methylation product, further with the ammonia generating uhlmann coupling reaction, the final with 4 - chloro-pyrrolo pyrimidine nucleophilic substitution reaction to obtain TNNI3K inhibitors. The present invention through the use of iridium metal complex as the methylation reaction catalyst, the reaction conditions are more moderate and high yield, without the need of high temperature and high pressure, nitrogen protection, severe conditions such as the reaction for a long time, the last step nucleophilic substitution reaction we adopt a microwave reactor greatly shorten the reaction time. (by machine translation)