45965-30-8Relevant articles and documents
Access to 2-pyridinylamide and imidazopyridine from 2-fluoropyridine and amidine hydrochloride
Chen, Lu,Huang, Shuo,Ji, Xiaoliang,Li, Jiaming,Li, Jian,Li, Yibiao,Liu, Jiasheng,Peng, Shiyong,Zhang, Kun
supporting information, p. 9292 - 9299 (2020/12/03)
Under catalyst-free conditions, an efficient method to synthesize 2-pyridinylamides has been developed, and the protocol uses inexpensive and readily available 2-fluoropyridine and amidine derivatives as the starting materials. Simultaneously, the copper-catalysed approach to imidazopyridine derivatives has been established with high chemoselectivity and regiospecificity. The results suggest that the nitrogen-heterocycles containing iodide substituents can also be compatible for the reaction via the cascade Ullmann-type coupling, and the nucleophilic substitution reaction provides the target products in a one-pot manner.
Synthetic method of 2-acetamido-5-chloropyridine
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Paragraph 0012; 0013; 0014; 0015; 0016; 0017, (2017/08/28)
The invention relates to a synthetic method of 2-acetamido-5-chloropyridine. The synthetic method comprises the following steps: making 2-amino-5-chloropyridine and acetic anhydride which are taken as raw materials continuously react in a mass ratio of 1 to (1.0-3.2) in a proper solvent at the temperature of 50 to 110 DEG C for 4 to 15 hours to generate a 2-amino-5-chloropyridine rough product; purifying to obtain a 2-amino-5-chloropyridine pure product. In the synthetic method, the raw materials are readily-available, and are reasonable in costs; meanwhile, in the preparation process, heavy metal and corrosive gas are not used, the reaction is mild, special requirements on reaction equipment are avoided, and ordinary corrosion-resistant equipment can be used for producing; moreover, the synthetic method is moderate in reaction conditions, and does not cause no any environmental pollution.
Convenient N-acetylation of amines in N,N-dimethylacetamide with N,N-carbonyldiimidazole
Chikkulapalli, Anil,Aavula, Sanjeev Kumar,Mona Np, Rifahath,Karthikeyan, Karthikeyan,Kumar C.H., Vinodh,Sulur G., Manjunatha,Sumathi, Shanmugam
supporting information, p. 3799 - 3803 (2015/06/08)
Dimethylacetamide (DMAc) acts as an efficient source of acetyl and dimethylamine gas in the presence of N,N-carbonyldiimidazole (CDI). Addition of amines to the reaction mixture delivers the corresponding amides in good to excellent yields. The acetylation of amines reported herein, which relies on the in situ generation of N-acetylimidazole on warming of DMAc with CDI at 120-125 °C, serves as a convenient alternative to other acetylation methods.