460739-44-0Relevant articles and documents
Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.
Buynak, John D,Vogeti, Lakshminarayana,Doppalapudi, Venkata Ramana,Solomon, George Martin,Chen, Hansong
, p. 1663 - 1666 (2007/10/03)
New C3-substituted beta-lactamase inhibitors were prepared and evaluated against representative class A and class C enzymes. It was possible to improve simultaneous inhibitory activity of both classes of serine hydrolase. Other inhibitors showed high selectivity for either the class C cephalosporinases or the class A penicillinases. This represents the first time that cephalosporin-derived inhibitors have demonstrated selectivity for the class A beta-lactamases.