460747-44-8

Basic information

• Product Name: Benzamide, 4-hydroxy-N-methoxy-N-methyl-
• CAS NO: 460747-44-8
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.191
• Mol File: 460747-44-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzamide, 4-hydroxy-N-methoxy-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-hydroxy-N-methoxy-N-methyl-(460747-44-8)
• EPA Substance Registry System: Benzamide, 4-hydroxy-N-methoxy-N-methyl-(460747-44-8)

Safety Data

• Hazardous Substances Data: 460747-44-8(Hazardous Substances Data)

Usage

General Description

Benzamide, 4-hydroxy-N-methoxy-N-methyl- is a chemical compound with the molecular formula C9H11NO3. It is a derivative of benzamide and contains a hydroxy group, a methoxy group, and a methyl group. Benzamide, 4-hydroxy-N-methoxy-N-methyl- is often used in the pharmaceutical industry for its potential therapeutic properties, including its ability to act as an analgesic and anti-inflammatory agent. It may also have applications in the field of organic synthesis and medicinal chemistry. Benzamide, 4-hydroxy-N-methoxy-N-methyl- is a valuable chemical with potential uses in various industrial and research applications.

Upstream product

• 201230-82-2 carbon monoxide 
• 540-38-5 p-Iodophenol 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 99-96-7 4-hydroxy-benzoic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 56442-22-9 benzyl 4-benzyloxybenzoate 
• 1486-51-7 p-(benzyloxy)benzoic acid 
• 1486-50-6 4-(benzyloxy)benzoic acid chloride 
• 252199-28-3 4-(benzyloxy)-N-methoxy-N-methylbenzamide 

Downstream Products

• 460747-45-9 4-hydroxy-3-iodo-N-methoxy-N-methylbenzamide 
• 643094-45-5 4-{[tert-butyl(dimethyl)silyl]oxy}-N-methoxy-N-methyl benzamide 
• 1227068-54-3 4-(3-chloropyrazin-2-yloxy)-N-methoxy-N-methylbenzenamide 
• 264883-48-9 N-Methoxy-N-methyl-4-[2-(1-pyrrolidinyl)ethoxy]-benzamide 

Relevant articles and documents

An Efficient synthesis of Weinreb amides and ketones via palladium nanoparticles on ZIF-8 catalysed carbonylative coupling

Heterogeneously catalysed carbonylative coupling reactions such as aminocarbonylation and Suzuki-carbonylation are reported using Pd nanoparticles supported on ZIF-8 for efficient and environmentally attractive synthesis of Weinreb amides and ketones from aryl bromides or iodides. The catalyst is air stable, offers high activity with very low palladium leaching and is recyclable. The presence of a phosphine ligand was required when aryl bromides were used as substrates, while no ligand was necessary when aryl iodides were used. the Partner Organisations 2014.

PYRAZINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS

Pyrazine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention

H3 receptor antagonists based on a 2-aminoethylbenzofuran skeleton have been discovered, which are potent in vitro at human and rat H 3 receptors, with Ki values of 0.1-5.8 nM. Analogues were discovered with potent (0.01-1 mg/kg) cognition and attention enhancing properties in animal models. One compound in particular, 4-(2-[2-(2(R)- methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile (ABT-239), combined potent and selective H3 receptor antagonism and excellent pharmacokinetic and metabolic properties across species, with full efficacy in two behavioral models: a five-trial inhibitory avoidance acquisition model in rat pups at 0.1 mg/kg and a social recognition memory model in adult rats at 0.01 mg/kg. Furthermore, this compound did not stimulate locomotor activity and showed high selectivity for the induction of behavioral efficacy versus central nervous system based side effects. The potency and selectivity of this compound and of analogues from this class support the potential of H3 receptor antagonists for the treatment of cognitive dysfunction.