461-57-4

Basic information

• Product Name: 1,1-difluoro-2-methoxyethane
• Synonyms: 1,1-Difluoro-2-methoxyethane; 2,2-Difluoroethyl methyl ether; ethane, 1,1-difluoro-2-methoxy-
• CAS NO: 461-57-4
• Molecular Formula: C₃H₆F₂O
• Molecular Weight: 96.0759
• Mol File: 461-57-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 27.711°C at 760 mmHg
• Flash Point: -24.851°C
• Density: 1.004g/cm³
• Vapor Pressure: 689.901mmHg at 25°C
• Refractive Index: 1.302
• CAS DataBase Reference: 1,1-difluoro-2-methoxyethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-difluoro-2-methoxyethane(461-57-4)
• EPA Substance Registry System: 1,1-difluoro-2-methoxyethane(461-57-4)

Safety Data

• Hazardous Substances Data: 461-57-4(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Mild, ether-like

Primary uses

a. Solvent
b. Refrigerant in industrial applications

Environmental properties

a. Low global warming potential
b. Non-ozone depleting

Environmental benefits

More environmentally friendly alternative to traditional refrigerants

Toxicity

Low toxicity

Safety

Considered safe for use in various applications

Potential alternative

To high-global-warming-potential hydrofluorocarbons in air conditioning and refrigeration systems

Upstream product

• 359-07-9 2-bromo-1,1-difluoroethane 
• 124-41-4 sodium methylate 
• 75-02-5 1-fluoroethylene 
• 36336-08-0 methyl hypofluorite 
• 74-87-3 methylene chloride 
• 135206-84-7 2,2-difluoroethyl 4-methylbenzenesulfonatemethyl6-bromo-3-(2,2-difluoroethoxy)picolinate 

Downstream Products

• 381-73-7 Difluoroacetic acid 

Relevant articles and documents

Method for preparing hydrofluoroether through two-step process

The invention discloses a method for preparing hydrofluoroether through a two-step process. With the method provided by the invention, p-toluensulfonyl chloride and fluorine-containing alcohol are subjected to a reaction to obtain p-toluenesulfonate, and the p-toluenesulfonate and sodium alkoxide are subjected to a Williamson ether synthetic reaction to obtain the hydrofluoroether. The method disclosed by the invention has the advantages of cheap and low-toxicity raw materials, mild and controllable reaction conditions, and high yield.

Methyl hypofluorite (MeOF) reactions with various fluoroolefins

The reaction of methyl hypofluorite (MeOF) with certain fluoroolefins, such as CF2=CF2, CF2=CFCF3, CF2=CFOCF3, CF2=CFOMe, CF2=CClF, CF2=CHF, CF2=CH2, CHF=CH2, CF2=CFCF=CF2, occurred in CD3CN or in the presence of NaF. Using neat MeOF in the presence of NaF was a novel method and gave good results. We observed that when more than three fluorine atoms are bonded to the C-C double bond, the addition products were obtained in mostly good yields.