461697-30-3

Basic information

• Product Name: 1H-Indole-2-carboxamide, N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1- methyl-
• CAS NO: 461697-30-3
• Molecular Formula: C23H27BN2O4
• Molecular Weight: 406.289
• Mol File: 461697-30-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Indole-2-carboxamide, N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1- methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2-carboxamide, N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1- methyl-(461697-30-3)
• EPA Substance Registry System: 1H-Indole-2-carboxamide, N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1- methyl-(461697-30-3)

Safety Data

• Hazardous Substances Data: 461697-30-3(Hazardous Substances Data)

Upstream product

• 461699-81-0 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 118618-61-4 1-methyl-1H-indole-2-carbonyl chloride 
• 16136-58-6 N-methyl-1H-indole-2-carboxylic acid 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 

Downstream Products

• 1603845-47-1 tert-butyl (2-(4-(4-(4-amino-3-(3-methoxy-4-(1-methyl-1H-indole-2-carboxamido)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazin-1-yl)ethyl)carbamate 
• 1603845-46-0 tert-butyl 4-(4-(4-amino-3-(3-methoxy-4-(1-methyl-1H-indole-2-carboxamido)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate 
• 330789-03-2 A-420983 

Relevant articles and documents

HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION

Provided are bifunctional small molecules of Formula (I): or pharmaceutically acceptable salts thereof, wherein M represents a small organic molecule which binds, covalently or non-covalently, a kinase, such as Her3 protein kinase; L1 represents a linker; and RH represents a hydrophobic group. An example of a compound of Formula (I) is a compound of Formula (II): Also provided are pharmaceutical compositions comprising a compound of Formula (I) or (II) and methods of using such compounds for treating proliferative diseases.

Thienopyridine and furopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Pyrazolopyrimidines as therapeutic agents

The present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, R2, and R3 are defined as described herein.