462-41-9

Basic information

• Product Name: 3-fluoropropan-1-amine
• Synonyms: 1-propanamine, 3-fluoro-; 3-Fluoropropan-1-amine
• CAS NO: 462-41-9
• Molecular Formula: C₃H₈FN
• Molecular Weight: 77.1007
• Mol File: 462-41-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 66.6°C at 760 mmHg
• Density: 0.884g/cm³
• Vapor Pressure: 151mmHg at 25°C
• Refractive Index: 1.368
• PKA: 8.98±0.10(Predicted)
• CAS DataBase Reference: 3-fluoropropan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoropropan-1-amine(462-41-9)
• EPA Substance Registry System: 3-fluoropropan-1-amine(462-41-9)

Safety Data

• Hazardous Substances Data: 462-41-9(Hazardous Substances Data)

Upstream product

• 462-24-8 3-fluoro-1-nitropropane 

Relevant articles and documents

Preparation method of fluorine-containing primary amine intermediate

The invention discloses a preparation method of a fluorine-containing primary amine intermediate. The method comprises the following steps: directly fluorinating an N-hydroxyalkyl phthalimide compound serving as a raw material under the action of an organic solvent and a Lewis acid catalyst to obtain an N-fluoroalkyl phthalimide intermediate, and reducing the intermediate to obtain the fluorine-containing primary amine. According to the method, the raw materials are cheap and easy to obtain, the process route is simple and easy to control, the N-hydroxyalkylphthalimide can be effectively promoted to generate the corresponding fluoride at a high conversion rate, meanwhile, the dehydrofluorination reaction in the fluorination process can be avoided, the yield of the fluoride intermediate is 85% or above, the purity reaches 97% or above, and the method is suitable for large-scale production.