4620-52-4

Basic information

• Product Name: ETHYL 4-METHYL-2-PHENYL-1,3-OXAZOLE-5-CARBOXYLATE
• Synonyms: ETHYL 4-METHYL-2-PHENYL-1,3-OXAZOLE-5-CARBOXYLATE
• CAS NO: 4620-52-4
• Molecular Formula: C₁₃H₁₃NO₃
• Molecular Weight: 231.25
• Mol File: 4620-52-4.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 4-METHYL-2-PHENYL-1,3-OXAZOLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-METHYL-2-PHENYL-1,3-OXAZOLE-5-CARBOXYLATE(4620-52-4)
• EPA Substance Registry System: ETHYL 4-METHYL-2-PHENYL-1,3-OXAZOLE-5-CARBOXYLATE(4620-52-4)

Safety Data

• Hazardous Substances Data: 4620-52-4(Hazardous Substances Data)

Upstream product

• 55-21-0 benzamide 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 141-97-9 ethyl acetoacetate 
• 4620-46-6 benzoic acid 1-ethoxycarbonyl-2-oxopropyl ester 
• 65-85-0 benzoic acid 
• 60050-48-8 3-benzamido-2-butenoic acid ethyl ester 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 2009-97-4 ethyl 2-diazo-3-oxobutanoate 
• 78120-34-0 (Z)-3-benzoylamino-but-2-enoic acid ethyl ester 

Downstream Products

• 51655-70-0 4-methyl-2-phenyl-oxazole-5-carboxylic acid amide 
• 91137-55-2 4-methyl-2-phenyl-1,3-oxazole-5-carboxylic acid 
• 248924-06-3 (4-methyl-2-phenyloxazol-5-yl)methanol 
• 625106-10-7 5-chloromethyl-4-methyl-2-phenyl-oxazole 
• 137267-35-7 4-ethyl-2-phenyloxazole-5-carboxylic acid 
• 1593269-73-8 C₃₃H₃₈N₂O₇ 
• 189271-78-1 ethyl 4-(bromomethyl)-2-phenyl-1,3-oxazole-5-carboxylate 
• 1593269-72-7 ethyl 4-{[{4-[(1-tert-butoxy-2-methyl-1-oxopropan-2yl) oxy]-3,5-dimethylbenzyl}(furan-2-ylmethyl) amino] methyl}-2-phenyl-1,3-oxazole-5-carboxylate 
• 1593269-74-9 tert-butyl 2-(4-{[{[2-phenyl-5-(dimethylcarbamoyl)-1,3-oxazol-4-yl]methyl}(furan-2-ylmethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate 
• 1593269-75-0 tert-butyl 2-(4-{[{[2-phenyl-5-(hydroxymethyl)-1,3-oxazol-4-yl]methyl}(furan-2-ylmethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate 
• 1593269-84-1 2-(4-{[{[2-phenyl-5-(hydroxymethyl)-1,3-oxazol-4-yl]-methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid 
• 1593269-85-2 2-(4-{[{[2-phenyl-5-(dimethylcarbamoyl)-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid 

Relevant articles and documents

Generation of Dimethyl Sulfoxide Coordinated Thermally Stable Halogen Cation Pools for C?H Halogenation

A method to generate halogen cation pools from the reaction of 1,2-dihaloethanes (hal=Br, I) and dimethyl sulfoxide (DMSO) for C?H halogenation of arenes and heteroarenes was reported. The initial reaction of DMSO and 1,2-dihaloethane generates the sulfur

Discovery of 2-phenylthiazole-4-carboxylic acid, a novel and potent scaffold as xanthine oxidase inhibitors

The xanthine oxidase (XO) plays an important role in producing uric acid, and therefore XO inhibitors are considered as one of the promising therapies for hyperuricemia and gout. We have previously reported a series of XO inhibitors with pyrazole scaffold to extend the chemical space of current XO inhibitors. Herein, we describe further structural optimization to explore the optimal heterocycle by replacing the thiazole ring of Febuxostat with 5 heterocycle scaffolds unexplored in this field. All of these efforts resulted in the identification of compound 8, a potent XO inhibitor (IC50 = 48.6 nM) with novel 2-phenylthiazole-4-carboxylic acid scaffold. Moreover, lead compound 8 exhibited hypouricemic effect in potassium oxonate-hypoxanthine-induced hyperuricemic mice. These results promote the understanding of ligand-receptor interaction and might help to design more promising XO inhibitors.

Biphenyl heterocyclic derivatives, their preparation and their use as medicaments (by machine translation)

The present invention relates to a novel biphenyl heterocyclic derivative represented by a general formula (I) and a preparation method thereof and use of a pharmaceutical composition containing the derivative for preparation of a drug for treating diabetes. The biphenyl heterocyclic derivative has extremely excellent hypoglycemic activity in vivo, and excellent in vivo safety and low liver toxicity risk of the compound having such a structure are unexpectedly found, and the novel biphenyl heterocyclic derivative may be used for preventing or treating diabetes.