462093-61-4

Basic information

• Product Name: 2-Propen-1-ol, 3,3-bis[3-(trifluoromethyl)phenyl]-
• CAS NO: 462093-61-4
• Molecular Formula: C17H12F6O
• Molecular Weight: 346.272
• Mol File: 462093-61-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-ol, 3,3-bis[3-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-ol, 3,3-bis[3-(trifluoromethyl)phenyl]-(462093-61-4)
• EPA Substance Registry System: 2-Propen-1-ol, 3,3-bis[3-(trifluoromethyl)phenyl]-(462093-61-4)

Safety Data

• Hazardous Substances Data: 462093-61-4(Hazardous Substances Data)

Upstream product

• 462093-57-8 ethyl 3,3-bis[3-(trifluoromethyl)phenyl]acrylate 
• 1868-00-4 3,3'-bis(trifluoromethyl)benzophenone 

Downstream Products

• 462093-65-8 3,3-bis[3-(trifluoromethyl)phenyl]prop-2-enyl chloride 

Relevant articles and documents

Novel compounds, their preparation and use

Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be u

N-3(9)-arylpropenyl-N-9(3)-propionyl-3,9-diazabicyclo[3.3.1]nonanes as μ-opioid receptor agonists. Effects on μ-affinity of arylalkenyl chain modifications

Two series of N-3-arylpropenyl-N-9-propionyl-3,9-diazabicyclo[3.3.1]nonanes (1b-j) and of the reverted N-3-propionyl-N-9-arylpropenyl isomers (2b-j) as analogues of the previously reported analgesic N-3(9)-cinnamyl-N-9(3)-propionyl-3,9-diazabicyclo[3.3.1]nonanes (DBN) (1a, 2a) were synthesised and their affinity and selectivity towards opioid μ-, δ- and κ-receptors were evaluated. Several compounds (1e,i,j-2d,e,f,g,j) exhibited a μ-affinity in the low nanomolar range with moderate or negligible affinity towards δ- and κ-receptors. The representative term N-9-(3,3-diphenylprop-2-enyl)-N-3-propionyl-DBN (2d) displayed in vivo (mouse) a potent analgesic effect (ED50 3.88 mg/kg ip) which favourably compared with that of morphine (ED50 5 mg/kg ip). In addition, 2d produced in mice tolerance after a period twice as long with morphine.