462122-40-3Relevant articles and documents
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.
Pellicciari, Roberto,Fiorucci, Stefano,Camaioni, Emidio,Clerici, Carlo,Costantino, Gabriele,Maloney, Patrick R,Morelli, Antonio,Parks, Derek J,Willson, Timothy M
, p. 3569 - 3572 (2002)
A series of 6alpha-alkyl-substituted analogues of chenodeoxycholic acid (CDCA) were synthesized and evaluated as potential farnesoid X receptor (FXR) ligands. Among them, 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA) was shown to be a very potent and selec