46230-70-0Relevant articles and documents
Mild and efficient synthesis of propargylamines by copper-catalyzed Mannich reaction
Bieber, Lothar W.,Da Silva, Margarete F.
, p. 8281 - 8283 (2007/10/03)
Terminal alkynes can be condensed with aqueous formaldehyde and primary or secondary amines to give secondary and tertiary propargylamines. The reaction is best carried out in DMSO under CuI catalysis. Terminal alkynes undergo mild and efficient aminomethylation with aqueous formaldehyde and secondary amines under CuI catalysis. In most cases high to nearly quantitative yields of tertiary propargylamines are obtained in DMSO solution at room temperature. Aromatic, aliphatic and silylated acetylenes as well as alkynols can be used. Primary amines are less reactive and satisfactory yields of secondary propargylamines are obtained only with phenylacetylene.
HALOGENATION OF HETEROCYCLIC ACETYLENIC MONO- AND DIAMINES
Kurbanov, A. I.,Turgunov, E.,Sirlibaev, T. S.
, p. 1135 - 1137 (2007/10/02)
Cyclic acetylenic monoamines, synthesized by the decomposition of the corresponding acetylenic aminoalcohols, and diamines, obtained by the Mannich reaction, give the products of the monoaddition of the halogens at the triple bond in aqueous solutions of acids.
