46279-13-4Relevant articles and documents
Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties
Kellett, Andrew,O'Connor, Mark,McCann, Malachy,McNamara, Mary,Lynch, Patrick,Rosair, Georgina,McKee, Vickie,Creaven, Bernie,Walsh, Maureen,McClean, Siobhan,Foltyn, Agnieszka,O'Shea, Denis,Howe, Orla,Devereux, Michael
, p. 1024 - 1027 (2011/03/16)
Three, structurally characterised, bis-phen Cu(ii) complexes of the phthalate isomers display rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells. The complexes induce relaxation of supercoiled plasmid DNA in the absence of external reducing agents and display efficient CT-DNA, Poly[d(A-T)]2 and Poly[d(G-C)]2 binding.
