4636-41-3

Basic information

• Product Name: 2-Hydroxy-3,7-dibromo-2,4,6-cycloheptatriene-1-one
• Synonyms: 2-Hydroxy-3,7-dibromo-2,4,6-cycloheptatriene-1-one;3,7-Dibromo-2-hydroxy-2,4,6-cycloheptatrien-1-one;3,7-Dibromotropolone
• CAS NO: 4636-41-3
• Molecular Formula: C₇H₄Br₂O₂
• Molecular Weight: 279.91
• Mol File: 4636-41-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Hydroxy-3,7-dibromo-2,4,6-cycloheptatriene-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-3,7-dibromo-2,4,6-cycloheptatriene-1-one(4636-41-3)
• EPA Substance Registry System: 2-Hydroxy-3,7-dibromo-2,4,6-cycloheptatriene-1-one(4636-41-3)

Safety Data

• Hazardous Substances Data: 4636-41-3(Hazardous Substances Data)

Upstream product

• 3008-39-7 cycloheptane-1,2-dione 
• 4584-68-3 3-bromo-2-hydroxy-2,4,6-cycloheptatrien-1-one 
• 533-75-5 2-hydroxy-2,4,6-cycloheptatrien-1-one 

Downstream Products

• 363-67-7 3,5,7-tribromotropolone 
• 13229-47-5 9-(2-amino-phenylsulfanyl)-11H-benzo[b]cyclohepta[e][1,4]thiazin-10-one 

Relevant articles and documents

A 13C nuclear magnetic resonance study of the reversible substituent migration in several 2-acyl and 2-silyl derivatives of tropolone. Troponoid-IV

The energy barrier for the reversible substituent migration was determined for a number of 2-acyl and 2-silyl derivatives of tropolone.The energy barrier is found to be dependent on the nature of the migrating group.Asymmetric monosubstitution on the ring shifts the equilibrium in favor of one dynamic isomer.In the two cases studied (3-bromotropolone and 3-bromotropolone acetate) it is found that the equilibrium is shifted towards the isomer bearing the bromine atom at the 7-position.

HINOKITIOL ANALOGUES, METHODS OF PREPARING AND PHARMACEUTICAL COMPOSITIONS THEREOF

Disclosed are analogues of hinokitiol, methods for preparing them, and pharmaceutical compositions thereof. Also disclosed are methods for their use in treating iron-related diseases.

α-Hydroxytropolones: A new class of potent inhibitors of inositol monophosphatase and other bimetallic enzymes

Mono- and polyhydroxytropolones are potent competitive inhibitors of inositol monophosphatase. Modeling studies indicate that this inhibition occurs most probably through a novel mode of action involving the chelation of the two magnesium ions in the active site. This is consistent with experimental data. Inhibition occurs when at least three oxygen atoms are present on the seven-membered ring, and only if they are contiguous to one another. In addition, those oxygens should not be protected. The corresponding six-membered rings showed no activity. Other bimetallic enzymes such as alkaline phosphatase (APase) or dopamine β-monooxygenase (DBM) are also inhibited (in a competitive or uncompetitive manner) by hydroxytropolones.