4646-80-4

Basic information

• Product Name: (1E)-1-phenylhex-1-en-3-one
• CAS NO: 4646-80-4
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.239
• Mol File: 4646-80-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 292.7°C at 760 mmHg
• Flash Point: 106.9°C
• Density: 0.984g/cm³
• Vapor Pressure: 0.0018mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: (1E)-1-phenylhex-1-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1E)-1-phenylhex-1-en-3-one(4646-80-4)
• EPA Substance Registry System: (1E)-1-phenylhex-1-en-3-one(4646-80-4)

Safety Data

• Hazardous Substances Data: 4646-80-4(Hazardous Substances Data)

Usage

Description

(1E)-1-phenylhex-1-en-3-one, also known as phenylhexenone, is a chemical compound belonging to the enone family, characterized by a molecular formula of C12H14O. It features a phenyl group attached to a hex-1-ene chain and functions as a ketone. This organic compound is recognized for its sweet, floral scent with a subtle fruity note, which makes it a favored ingredient in the creation of various consumer products.

Uses

Used in Flavor and Fragrance Industry:
(1E)-1-phenylhex-1-en-3-one is utilized as a flavoring agent and fragrance, capitalizing on its appealing aroma to enhance the sensory experience of food and perfumery products. Its sweet and floral scent profile with a fruity undertone allows it to contribute positively to the overall smell and taste of these products.
Used in Pharmaceutical Production:
In the pharmaceutical sector, (1E)-1-phenylhex-1-en-3-one serves as a synthetic intermediate. It plays a crucial role in the synthesis of various pharmaceuticals and organic compounds, facilitating the development of new medications and contributing to advancements in healthcare.
However, it is imperative to exercise caution and adhere to safety guidelines when handling (1E)-1-phenylhex-1-en-3-one due to its potential health hazards, ensuring that its benefits are realized without compromising safety.

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Relevant articles and documents

Facile Synthesis of Polysubstituted 2-Pyrones via TfOH-Mediated Ring Expansion of 2-Acylcyclopropane-1-carboxylates

A facile route to polysubstituted 2-pyrones from readily available 2-acylcyclopropane-1-aryl-1-carboxylates mediated by TfOH is reported. The strongly donating 1-aryl group is important for directing the C-C bond cleavage of the donor-acceptor cyclopropane ring, which then leads to the formation of the 2-pyrone ring through lactonization.

Sequential aldol Condensation-Transition metal-Catalyzed addition reactions of aldehydes, methyl ketones, and arylboronic acids

Sequential aldol condensation of aldehydes with methyl ketones followed by transition metal-catalyzed addition reactions of arylboronic acids to form β-substituted ketones is described. By using the 1,1′;-spirobiindane- 7,7′;-diol (SPINOL)-based phosphite, an asymmetric version of this type of sequential reaction, with up to 92% ee, was also realized. Our study provided an efficient method to access β-substituted ketones and might lead to the development of other sequential/tandem reactions with transition metal-catalyzed addition reactions as the key step.

Process for separating zinc salts from zinc alcoholates or zinc amides containing non-aqueous synthesis solvents

A process for the removal of zinc from organic solutions containing zinc alcoholates or zinc amides comprises addition of an alkylating, arylating, acylating or silylating agent in the presence of a precipitating agent having at least two nitrogen donors followed by separation of the precipitated solid.