46503-52-0

Basic information

• Product Name: 1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL) ETHANONE
• Synonyms: AURORA KA-666;1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL)ETHANONE;1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL) ETHANONE;1-(2,4-DICHLOROPHENYL)-2-IMIDAZOL-1-YL-ETHANONE;2',4'-DICHLORO-2-IMIDAZOLYLACETOPHENONE;2'-(1H-IMIDAZOLE-1-YL)-2,4-DICHLOROACETOPHENONE;1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-one;2,4'-Dichloro Phenyl-2-Imidazole-1-Ethanone
• CAS NO: 46503-52-0
• Molecular Formula: C₁₁H₈Cl₂N₂O
• Molecular Weight: 255.1
• EINECS: 256-273-3
• Mol File: 46503-52-0.mol
• Article Data: 38

Chemical Properties

• Melting Point: 76-78 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 441.1 °C at 760 mmHg
• Flash Point: 220.6 °C
• Appearance: Off-white solid
• Density: 1.38 g/cm³
• PKA: 5.97±0.10(Predicted)
• CAS DataBase Reference: 1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL) ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL) ETHANONE(46503-52-0)
• EPA Substance Registry System: 1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL) ETHANONE(46503-52-0)

Safety Data

• Hazardous Substances Data: 46503-52-0(Hazardous Substances Data)

Usage

General Description

The chemical 1-(2,4-dichlorophenyl)-2-(1H-imidazole-1-yl) ethanone is a white to off-white powder that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a ketone compound that contains a dichlorophenyl group and an imidazole ring. This chemical is often used as a building block in the production of antifungal, antibacterial, and anti-inflammatory drugs. It is also utilized in the development of new chemical entities for various therapeutic applications. Additionally, it may have potential uses as a pesticide and in other industrial applications.

Upstream product

• 288-32-4 1H-imidazole 
• 4252-78-2 2,2',4'-trichloroacetophenone 
• 2631-72-3 2,4-dichlorophenacyl bromide 
• 78344-77-1 2-diazo-1-(2,4-dichlorophenyl)ethanone 
• 7732-18-5 water 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 
• 541-73-1 1,3-Dichlorobenzene 

Downstream Products

• 104061-06-5 1-[2-(2,4-dichlorophenyl)-2-(4-phenyl-piperazine)vinyl]-1H-imidazole 
• 78202-19-4 2-(2,4-dichlorophenyl)-1-(1-imidazolyl)-butan-2-ol 
• 78202-17-2 2-(2,4-dichlorophenyl)-1-(1-imidazolyl)-pentan-2-ol 
• 78202-26-3 2-(2,4-Dichloro-phenyl)-1-imidazol-1-yl-hex-5-en-2-ol 
• 344318-22-5 2-(2,4-Dichloro-phenyl)-1-imidazol-1-yl-3-methyl-pent-4-en-2-ol 
• 78202-15-0 2-(2,4-dichlorophenyl)-1-(1-imidazolyl)-pent-4-en-2-ol 
• 70827-17-7 1-[2-hydroxy-2-(2,4-dichlorophenyl)hexyl]imidazole 
• 78202-20-7 α-t-butyl-α-(o,p-dichlorophenyl)-1H-imidazole-1-ethanol 
• 85473-16-1 2-(2,4-Dichloro-phenyl)-1-imidazol-1-yl-heptan-2-ol 
• 85473-17-2 2-(2,4-dichlorophenyl)-1-(1-imidazolyl)-octan-2-ol 
• 78202-27-4 2-(2,4-Dichloro-phenyl)-1-imidazol-1-yl-decan-2-ol 
• 78202-28-5 2-(2,4-Dichloro-phenyl)-1-imidazol-1-yl-dodecan-2-ol 
• 78202-37-6 1-[[2-(2,4-dichlorophenyl)-oxiranyl]methyl]-1H-imidazole 
• 78202-21-8 2-(2,4-Dichloro-phenyl)-1-imidazol-1-yl-3-methyl-butan-2-ol 

Relevant articles and documents

One pot synthesis of α-N-heteroaryl ketone derivatives from aryl ketones using aqueous NaICl2

A simple and efficient method for the synthesis of α-heteroaryl ketones from aryl ketones and amine using aqueous sodium dichloroiodate is established. This method is mild, operationally simple, has a short reaction time, and easy workup procedure to afford the corresponding α-N-heteroaryl ketone derivatives in moderate to good yield.

BuChE-IDO1 inhibitor as well as preparation method and application thereof

The invention relates to the field of medicines, and particularly discloses a BuChE-IDO1 inhibitor as well as a preparation method and application thereof. The 7-chlorine-3-substituted benzothiophene part of sertaconazole is chemically modified, the influence of the 7-chlorine-3-substituted benzothiophene part of sertaconazole on the in-vitro inhibitory activity of AChE, BuChE and IDO1 is explored, the target compound is further optimized, and the technical problems that an existing BuChE-IDO1 inhibitor is poor in pertinence and safety are solved. What is explored is that an appropriate substituent group introduced to a 2-benzothiazole ring can form additional interaction with surrounding amino acids and heme iron, so that the binding affinity of the analogue with BuChE and IDO1 is increased, and a new idea is broadened for more efficient and targeted treatment of advanced AD diseases.

Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents

Herein, based on the theory of bioisosterism, a series of novel miconazole analogues containing selenium were designed, synthesized and their inhibitory effects on thirteen strains of pathogenic fungi were evaluated. It is especially encouraging that all the novel target compounds displayed significant antifungal activities against all tested strains. Furthermore, all the target compounds showed excellent inhibitory effects on fluconazole-resistant fungi. Subsequently, preliminary mechanistic studies indicated that the representative compound A03 had a strong inhibitory effect on C.alb. CYP51. Moreover, the target compounds could prevent the formation of fungi biofilms. Further hemolysis test verified that potential compounds had higher safety than miconazole. In addition, molecular docking study provided the interaction modes between the target compounds and C.alb. CYP51. These results strongly suggested that some target compounds are promising as novel antifungal drugs.