4663-83-6 Usage
Description
Buramate is a chemical compound with potential applications in various fields, including pharmaceuticals and medicine.
Uses
Used in Pharmaceutical Industry:
Buramate is used as an anticonvulsant and antipsychotic agent for the treatment of epilepsy and mental disorders, respectively.
Used in Chemical Synthesis:
Buramate is used as a precursor for the synthesis of more complex compounds with antibacterial activity, as well as for the development of new antimalarial compounds.
Originator
Buramate,Chauny and Cirey
Manufacturing Process
Into a vessel provided with efficient stirring means there are gradually
introduced, while maintaining the temperature at 40°C, 535.0 g of
benzylamine and 440.0 g of cyclic carbonate of glycol. The mass obtained is
maintained at a temperature 40-50°C for about 12 h. Upon cooling, there is
obtained a glycol benzylcarbamate as a white crystalline, melting point at
40°C, yield 92%.
Check Digit Verification of cas no
The CAS Registry Mumber 4663-83-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,6,6 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 4663-83:
(6*4)+(5*6)+(4*6)+(3*3)+(2*8)+(1*3)=106
106 % 10 = 6
So 4663-83-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO3/c12-6-7-14-10(13)11-8-9-4-2-1-3-5-9/h1-5,12H,6-8H2,(H,11,13)
4663-83-6Relevant articles and documents
Synthesis of 1,3-disubstituted symmetrical/unsymmetrical ureas via Cs2CO3-catalyzed transamination of ethylene carbonate and primary amines
Jagtap, Sachin R.,Patil, Yogesh P.,Panda, Anil G.,Bhanage, Bhalchandra M.
experimental part, p. 2093 - 2100 (2009/10/17)
Cs2CO3-catalyzed transamination of primary amines and ethylene carbonate proceeds to form 1,3-disubstituted symmetrical/unsymmetrical ureas in excellent yields. The effect of different reaction parameters such as influences of bases, temperature, and reaction time were investigated for the title reaction.
BEHAVIOR OF HYDROXYURETHANES (β-HYDROXYETHYL CARBAMATES)
Rappoport, L. Ya.,Gavrilova, O. P.,Zacheslavskaya, R. Kh.,Trostyanskaya, I. I.,Petrov, G. N.
, p. 1274 - 1277 (2007/10/02)
The transesterification of β-hydroxyethyl carbamates, accompanied by elimination of ethylene glycol from each pair of interacting molecules, was studied.The factor which determines the behavior of these compounds is the formation of an intramolecular hydrogen bond between the hydroxyl and the carbonyl of the urethane group.The existence of cyclic forms formed through the hydrogen bond in β-hydroxyethyl carbamates was demonstrated by IR and NMR spectroscopy and was confirmed by quantum-chemical calculations.
