4664-00-0

Basic information

• Product Name: QUINOLINIMIDE
• Synonyms: 2,3-PYRIDINEDICARBOXAMIDE;AKOS 93366;5H-PYRROLO[3,4-B]PYRIDINE-5,7(6H)-DIONE;QUINOLINIMIDE;PYRROLO[3,4-B]PYRIDINE-5,7-DIONE;2,3-pyridinedicarboximide;3-azaphthalimid;pyridinedicarboxamide
• CAS NO: 4664-00-0
• Molecular Formula: C₇H₄N₂O₂
• Molecular Weight: 148.12
• EINECS: 225-107-1
• Product Categories: Pyridine;Miscellaneous Reagents;Aromatics;Heterocycles;Heterocycle-Pyridine series
• Mol File: 4664-00-0.mol
• Article Data: 17

Chemical Properties

• Melting Point: 233-234°C
• Boiling Point: 268.69°C (rough estimate)
• Appearance: Light yellow solid
• Density: 1.4015 (rough estimate)
• Refractive Index: 1.5300 (estimate)
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane, Ether, Ethyl Acetate, Methanol
• PKA: 8.08±0.20(Predicted)
• CAS DataBase Reference: QUINOLINIMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: QUINOLINIMIDE(4664-00-0)
• EPA Substance Registry System: QUINOLINIMIDE(4664-00-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 4664-00-0(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

Uses

Quinolinimide (cas# 4664-00-0) is a compound useful in organic synthesis.

InChI:InChI=1/C7H4N2O2/c10-6-4-1-2-8-3-5(4)7(11)9-6/h1-3H,(H,9,10,11)

Upstream product

• 60-35-5 acetamide 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 57-13-6 urea 
• 73112-09-1 2-cyanopyridine-3-carboxylic acid 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 4663-94-9 pyridine-2,3-dicarboxamide 
• 108-24-7 acetic anhydride 

Downstream Products

• 5657-51-2 7H-furo[3,4-b]pyridin-5-one 
• 4663-94-9 pyridine-2,3-dicarboxamide 
• 1462-86-8 3-amino-pyridine-2-carboxylic acid 
• 115012-09-4 6,7-Dihydro-7-hydroxy-5H-pyrrolo<3,4-b>pyridin-5-one 
• 115012-10-7 5,6-dihydro-5-hydroxy-7H-pyrrolo<3,4-b>pyridin-7-one 
• 115012-11-8 2-(hydroxymethyl)nicotinamide 
• 115012-12-9 3-hydroxymethyl-2-pyridinecarboxamide 
• 6789-51-1 6-methyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 
• 18184-75-3 6-benzyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 
• 18184-79-7 6-phenethyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 
• 442882-27-1 6-(4-methoxybenzyl)-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 
• 115062-74-3 6-(2,6-Dimethyl-phenyl)-pyrrolo[3,4-b]pyridine-5,7-dione 
• 6538-81-4 6-Phenylpyrrolo<3,4-b>pyridine-5,7(6H)-dione 
• 37458-38-1 6-(4-chloro-phenyl)-pyrrolo[3,4-b]pyridine-5,7-dione 

Relevant articles and documents

Method for preparing 6,7-dihydro-5H-pyrrolo-pyridine hydrochloride

The invention discloses a preparation method for preparing 6,7-dihydro-5H-pyrrolo-pyridine hydrochloride. The method is characterized in that a target product 6,7-dihydro-5H-pyrrolo-pyridine hydrochloride is obtained through lactamization, reduction and salifying by taking furo[3,4-b]pyridine-5,7-dione as an original raw material. The compound is an important medical intermediate.

(S, S) - 2,8-diazabicyclo [4.3.0] nonane preparation method

The invention relates to a novel preparation method of (S,S)-2,8-diazabicyclo[4.3.0]. The method comprises the steps that: 2,3-pyridine dicarboxylic acid derivative and amide are subjected to condensation, such that 2,3-pyridine dicarboximide is formed; 2,3-pyridine dicarboximide is subjected to protection and hydrogenation reduction, such that 8-substituted-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane is produced; the product is reduced in a borohydride reduction system, such that 8-substituted-2,8-diazabicyclo[4.3.0]nonane is obtained; the product is subjected to optical-active organic acid resolution, such that 8-site protection group is removed, and the final product is obtained. Or, 2,3-pyridine dicarboximide is directly subjected to hydrogenation reduction, such that 7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane is produced; the product is directly reduced in a borohydride reduction system, such that 2,8-diazabicyclo[4.3.0]nonane is produced; the 2,8-diazabicyclo[4.3.0]nonane is subjected to optical-active organic acid resolution, such that the final product is directly obtained. The method provided by the invention is advantaged in simple reaction route. The raw materials are cheap and easy to obtain. The reaction conditions are mild and easy to control. The method is suitable for industrialized productions.

Synthetic method of 6-(1-phenyl-ethyl)-pyrrolo[3,4-b]pyridyl-5,7-dione

The invention particularly relates to a synthetic method of 6-(1-phenyl-ethyl)-pyrrolo[3,4-b]pyridyl-5,7-dione. The synthetic method is characterized in that 2,3-pyridinedicarboxylic acid and urea are subjected to melt reaction to produce amide, then amide reacts with methylbenzylamine to produce a crude product 6-(1-phenyl-ethyl)-pyrrolo[3,4-b]pyridyl-5,7-dione which is subjected to chiral resolution to obtain the target product 6-(1-phenyl-ethyl)-pyrrolo[3,4-b]pyridyl-5,7-dione. The synthetic method has the advantages that the reaction steps are simple and short, the reaction is quick, no by-product is produced, environmental pollution is reduced, the reaction yield is high, the separation efficiency of a chiral chromatographic column is relatively high, and the product purity is improved.