4667-71-4 Usage
Molecular Structure
The compound has a complex structure consisting of an isoindole-1,3(2H)-dione ring and a 2-[2-(1H-benzimidazol-2-yl)ethyl]group attached to it.
Isoindole-1,3(2H)-dione ring
A five-membered ring with two nitrogen atoms and two carbonyl groups.
2-[2-(1H-benzimidazol-2-yl)ethyl]group
A side chain attached to the isoindole ring, containing a benzimidazole structure.
Benzimidazole structure
The benzimidazol-2-yl group is a fused bicyclic structure containing a benzene ring fused to an imidazole ring.
Benzene ring
A six-membered aromatic ring with six carbon atoms and alternating single and double bonds.
Imidazole ring
A five-membered aromatic ring with four carbon atoms and one nitrogen atom.
Biological and pharmacological activities
1H-Isoindole-1,3(2H)-dione, 2-[2-(1H-benzimidazol-2-yl)ethyl]may exhibit biological or pharmacological activities due to its unique structure.
Potential applications
Further research may be needed to explore the compound's possible uses in medicine or other fields.
Research potential
The compound's structure and properties may warrant further investigation to determine its potential applications and effects.
Exploration of biological activities
Studying the compound's interactions with biological systems and potential therapeutic uses.
Analysis of chemical properties
Investigating the compound's reactivity, stability, and other chemical characteristics.
Check Digit Verification of cas no
The CAS Registry Mumber 4667-71-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,6,6 and 7 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4667-71:
(6*4)+(5*6)+(4*6)+(3*7)+(2*7)+(1*1)=114
114 % 10 = 4
So 4667-71-4 is a valid CAS Registry Number.
4667-71-4Relevant articles and documents
Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives
Czopek, Anna,Partyka, Anna,Bucki, Adam,Paw?owski, Maciej,Ko?aczkowski, Marcin,Siwek, Agata,G?uch-Lutwin, Monika,Koczurkiewicz, Paulina,P?kala, El?bieta,Jaromin, Anna,Tyliszczak, Bo?ena,Weso?owska, Anna,Zagórska, Agnieszka
, (2020)
In this study, a series of compounds derived from 4-methoxy-1H-isoindole-1,3(2H)-dione, potential ligands of phosphodiesterase 10A and serotonin receptors, were investigated as potential antipsychotics. A library of 4-methoxy-1H-isoindole-1,3(2H)-dione derivatives with various amine moieties was synthesized and examined for their phosphodiesterase 10A (PDE10A)-inhibiting properties and their 5-HT1A and 5-HT7 receptor affinities. Based on in vitro studies, the most potent compound, 18 (2-[4-(1H-benzimidazol-2-yl)butyl]-4-methoxy-1H-isoindole-1,3(2H)-dione), was selected and its safety in vitro was evaluated. In order to explain the binding mode of compound 18 in the active site of the PDE10A enzyme and describe the molecular interactions responsible for its inhibition, computer-aided docking studies were performed. The potential antipsychotic properties of compound 18 in a behavioral model of schizophrenia were also investigated.
