467442-68-8Relevant articles and documents
Pyrimidinylpyrroloquinolones as highly potent and selective PDE5 inhibitors for treatment of erectile dysfunction
Sui, Zhihua,Guan, Jihua,Macielag, Mark J.,Jiang, Weiqin,Zhang, Suying,Qiu, Yuhong,Kraft, Patricia,Bhattacharjee, Sheela,John, T. Matthew,Haynes-Johnson, Donna,Clancy, Joanna
, p. 4094 - 4096 (2007/10/03)
A series of N-pyrimidinylpyrroloquinolones were discovered as extremely potent and selective PDE5 inhibitors. Representative compounds demonstrated in vivo efficacy in dog erectile dysfunction models and are orally bioavailable.