46797-67-5

Basic information

• Product Name: (1S,2R)-(+)-2-(methylamino)-1,2-diphenylethanol
• Synonyms: (1S,2R)-(+)-2-(methylamino)-1,2-diphenylethanol
• CAS NO: 46797-67-5
• Molecular Weight: 227.306
• Mol File: 46797-67-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: (1S,2R)-(+)-2-(methylamino)-1,2-diphenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R)-(+)-2-(methylamino)-1,2-diphenylethanol(46797-67-5)
• EPA Substance Registry System: (1S,2R)-(+)-2-(methylamino)-1,2-diphenylethanol(46797-67-5)

Safety Data

• Hazardous Substances Data: 46797-67-5(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 134-81-6 benzil 
• 1439-07-2 trans-Stilbene oxide 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 550-58-3 N-methylamino-2 diphenyl-1,2 ethanol erythro 
• 100-46-9 benzylamine 
• 6343-54-0 N-benzylformamide 
• 17105-71-4 N-methyl-N-benzylformamide 
• 54852-85-6 N-methylamino-2 diphenyl-1,2 ethanol 
• 104936-74-5 N-Benzyl-N'-tert-butyl-N-methyl-formamidine 
• 100-52-7 benzaldehyde 
• 39664-86-3 (+/-)-N-(threo-α'-hydroxy-bibenzyl-α-yl)-formamide 
• 94675-08-8 (+/-)-N-(threo-α'-hydroxy-bibenzyl-α-yl)-N-methyl-acetamide 
• 94675-08-8 (+/-)-N-(erythro-α'-hydroxy-bibenzyl-α-yl)-N-methyl-acetamide 

Downstream Products

• 550-58-3 (1S,2S)-1,2-diphenyl-2-(N-methyl)aminoethanol 
• 71653-76-4 (+/-)-(threo-α'-chloro-bibenzyl-α-yl)-methyl-amine; hydrochloride 
• 84494-64-4 3-methyl-r-2,c-4,c-5-triphenyloxazolidine 
• 84494-64-4 3-methyl-r-2,c-4,t-5-triphenyloxazolidine 
• 108826-61-5 (2S,4R,5R)-3-Methyl-4,5-diphenyl-[1,2,3]oxathiazolidine 2-oxide 
• 108826-61-5 (2R,4R,5R)-3-Methyl-4,5-diphenyl-[1,2,3]oxathiazolidine 2-oxide 
• 6103-39-5 4-methyl-5,6-diphenylmorpholine-2,3-dione 
• 550-58-3 DL-threo-2-methylamino-1.2-diphenyl-ethanol 
• 1380325-31-4 (R)-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethyl-3-phenylpropanamide 
• 1380325-33-6 CF₃O₃S^(1-)*C₂₅H₂₆NO⁽¹⁺⁾ 
• 1380325-34-7 (R)-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethylhexanamide 
• 1380325-35-8 (R)-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethylbutanamide 
• 1380325-36-9 (S)-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethylbutanamide 
• 1380325-37-0 (R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylhexanamide 

Relevant articles and documents

Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides

The direct, catalytic substitution of unactivated alcohols remains an undeveloped area of organic synthesis. Moreover, catalytic activation of this difficult electrophile with predictable stereo-outcomes presents an even more formidable challenge. Described herein is a simple iron-based catalyst system which provides the mild, direct conversion of secondary and tertiary alcohols to sulfonamides. Starting from enantioenriched alcohols, the intramolecular variant proceeds with stereoinversion to produce enantioenriched 2- and 2,2-subsituted pyrrolidines and indolines, without prior derivatization of the alcohol or solvolytic conditions.

Enantioselective synthesis of (1S,2R)-ephenamine

A short and efficient enantioselective synthesis of (1S,2R)-ephenamine is described employing Sharpless asymmetric dihydroxylation and regioselective nucleophilic opening of a cyclic sulfite as the key steps.

A simple, scalable synthetic route to (+)- and (-)-pseudoephenamine

A three-step synthesis of pseudoephenamine suitable for preparing multigram amounts of both enantiomers of the auxiliary from the inexpensive starting material benzil is described. The sequence involves synthesis of the crystalline monomethylimine derivat