468064-37-1

Basic information

• Product Name: 1-(3-bromo-4-cyano-2-hydroxyphenyl)-3-(2-bromophenyl)urea
• Synonyms: N-(3-bromo-4-cyano-2-hydroxyphenyl)-N'-(2-bromophenyl)urea; urea, N-(3-bromo-4-cyano-2-hydroxyphenyl)-N'-(2-bromophenyl)-
• CAS NO: 468064-37-1
• Molecular Formula: C₁₄H₉Br₂N₃O₂
• Molecular Weight: 411.0482
• Mol File: 468064-37-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 406.14°C at 760 mmHg
• Flash Point: 199.426°C
• Density: 1.942g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.736
• CAS DataBase Reference: 1-(3-bromo-4-cyano-2-hydroxyphenyl)-3-(2-bromophenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-bromo-4-cyano-2-hydroxyphenyl)-3-(2-bromophenyl)urea(468064-37-1)
• EPA Substance Registry System: 1-(3-bromo-4-cyano-2-hydroxyphenyl)-3-(2-bromophenyl)urea(468064-37-1)

Safety Data

• Hazardous Substances Data: 468064-37-1(Hazardous Substances Data)

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

A urea derivative is a compound that contains a urea functional group, which is a common structural motif in organic chemistry and pharmaceuticals.

Explanation

Halogenated compounds are those in which one or more hydrogen atoms have been replaced by halogen atoms, in this case, bromine.

Explanation

The cyanogen group is a functional group consisting of a carbon-carbon triple bond and a carbon-nitrogen triple bond, which is present in this compound.

Explanation

The hydroxyl group is a functional group consisting of an oxygen atom bonded to a hydrogen atom, which is present in this compound.

Explanation

The compound has potential applications in the development of new drugs or as a building block for other complex organic molecules.

Explanation

Due to its chemical structure and potential reactivity, it is important to handle this compound carefully and follow safety guidelines to minimize risks in a laboratory setting.

Urea derivative

Contains a urea functional group (NH2-CO-NH2)

Halogenated compound

Contains two bromine atoms (Br)

Cyanogen group

Contains a nitrile group (C≡N)

Hydroxyl group

Contains a hydroxyl group (-OH)

Application

Used in organic synthesis and pharmaceutical research

Safety precautions

Handle with caution and follow proper safety protocols

Upstream product

• 1592-00-3 2-bromophenyl isocyanate 
• 676124-40-6 3-bromo-4-cyano-2-hydroxyaniline 
• 18495-15-3 3-hydroxy-4-nitrobenzonitrile 
• 873-62-1 m-cyanophenol 
• 203201-43-8 2-bromo-3-cyano-6-nitrophenol 

Relevant articles and documents

Evaluation of Potent and Selective Small-Molecule Antagonists for the CXCR2 Chemokine Receptor

N,N′-Diarylureas were prepared, and the structure-activity relationship relative to the CXCR2 receptor was examined. This led to the identification of a potent and highly selective CXCR2 antagonist, which in addition was shown to be functionally active bo

IL-8 RECEPTOR ANTAGONISTS

This invention relates to novel compounds and a novel use of phenyl ureas in the treatment of disease scates mediated by the chemokine, Interleukin-8 (IL-8). In particular, this invention relates to the novel compounds of Formula (Ia) and their use in treating chemokine mediated diseases wherein the chemokine binds to an IL-8 a or b receptor. Compounds of Formula (Ia) are represented by the structure: STR1 wherein interalia, X is oxygen or sulfur;Rb is NR 6 R. sub.7, alkcyl, aryl, arylC 1-4 alkyl, aryl C 2-4 alkenyl, heteroaryl, heteroarylC 1-4 alkyl, heteroarylC 2-4 alkenyl, heterocyclic or heterocyclic C 1-4 alkyl, or a heterocyclic C 2-4 alkenyl moiety, camphor, all of which may be optionally substituted; R 1 is independently selected from hydrogen; halogen; nitro; cyano; C 1-10 alkyl; halosubstituted C 1-10 alkyl; C 2-10 alkoxy; halosubstituted C 1-10 alkoxy; azide; (CR. sub.8 R 8)q S(O) t R 4 ; hydroxy; hydroxy substituted C 1-4 alkyl; aryl; aryl C 1-4 alkyl; aryl C 2-10 alkenyl; aryloxy; aryl C 1-4 alkyloxy; heteroaryl; heteroarylalkyl; heteroaryl C 2-10 alkenyl; heteroaryl C 1-4 alkyloxy; heterocyclic; heterocyclic C 1-4 alkyl; heterocyclicC 1-4 alkyloxy; heterocyclic C 2-10 alkenyl; q is 0 or an integer having a value of 1 to 10; n is an integer having a value of 1 to 3;m is an integer having a value of 1 to 3; Y is hydrogen; halogen; nitro; cyano; halosubstituted C 1-10 alkyl; C 1-10 alkyl; C 2-10 alkenyl C. sub.1-10 alkoxy; halosubstituted C 1-10 alkoxy; azide; (CR 8 R. sub.8)qS(O) t R 4, (CR 8 R 8)qOR 4 ; hydorxy; hydroxy substituted C. sub.1-4 alkyl; aryl; aryl C 1-4 alkyl; aryloxy; arylC. sub.1-4 alkyloxy; aryl C 2-10 alkenyl; heteroaryl; heteroarylalkyl; heteroaryl C 1-4 alkyloxy; heteroaryl C 2-10 alkenyl; heterocyclic, heterocyclic C 1-4 alkyl; heterocyclicC 2-10 alkenyl;or a pharmaceutically acceptable salt thereof.