468066-71-9Relevant articles and documents
Total synthesis of the indolizidinium alkaloid ficuseptine
Bracher, Franz,Daab, Jochen
, p. 2288 - 2291 (2007/10/03)
The first total synthesis of ficuseptine [4,6-bis(4-methoxyphenyl)-1,2,3-trihydroindolizidinium chloride] (1), an alkaloid from Ficus septica, is described. The crucial steps in this five-step synthesis are a palladium-catalyzed bis(arylation) of a dibromopyridine under Suzuki conditions and a palladium-catalyzed alkynylation of an iodopyridine under Sonogashira conditions, as well as a novel Sandmeyer-type iodination of a 2-aminopyridine derivative. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.