468741-39-1Relevant articles and documents
Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile
Velaparthi, Upender,Liu, Peiying,Balasubramanian, Balu,Carboni, Joan,Attar, Ricardo,Gottardis, Marco,Li, Aixin,Greer, Ann,Zoeckler, Mary,Wittman, Mark D.,Vyas, Dolatrai
, p. 3072 - 3076 (2008/02/07)
A series of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) were examined in which the pendant imidazole moiety was replaced to improve selectivity for IGF-1R inhibition over cytochrome P450 (CYP). Synthesis and SAR of these compounds is presented.