468741-42-6

Basic information

• Product Name: (S)-3-(4-(2-(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-2-oxo-1,2-dihydropyridin-3-yl)-7-methyl-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)propanenitrile
• Synonyms: (S)-3-(4-(2-(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-2-oxo-1,2-dihydropyridin-3-yl)-7-methyl-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)propanenitrile;(S)-3-(4-(2-(4-(2-(3-chlorophenyl)-2-hydroxyethylaMino)-2-oxo-1;4-[2-[4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-1,2-dihydro-2-oxo-3-pyridinyl]-7-methyl-1H-benzimidazol-5-yl]-1-piperazinepropanenitrile;(S)-3-(4-(2-(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-2-oxo-1,2-dihydropyridin-3-yl)-7-methyl-1H-enzo[d]imidazol-5-yl)piperazin-1-yl)propanenitrile;(S)-3-(4-(2-(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-2-oxo-1,2-dihydropyridin-3-yl)-7-methyl-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)enitrile;VVIPLSCLYCWUQT-XMMPIXPASA-N
• CAS NO: 468741-42-6
• Molecular Formula: C₂₈H₃₀ClN₇O₂
• Molecular Weight: 532.0365
• Mol File: 468741-42-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.42
• CAS DataBase Reference: (S)-3-(4-(2-(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-2-oxo-1,2-dihydropyridin-3-yl)-7-methyl-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(4-(2-(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-2-oxo-1,2-dihydropyridin-3-yl)-7-methyl-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)propanenitrile(468741-42-6)
• EPA Substance Registry System: (S)-3-(4-(2-(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-2-oxo-1,2-dihydropyridin-3-yl)-7-methyl-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)propanenitrile(468741-42-6)

Safety Data

• Hazardous Substances Data: 468741-42-6(Hazardous Substances Data)

Usage

General Description

The chemical "(S)-3-(4-(2-(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-2-oxo-1,2-dihydropyridin-3-yl)-7-methyl-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)propanenitrile" is a complex organic compound with a unique structure. It contains a piperazine ring, a cyanide group, and multiple aromatic rings, including a benzo[d]imidazole ring. It also includes a dihydropyridine moiety and a chlorophenyl group. This chemical likely exhibits a variety of pharmacological properties due to its diverse structure, and may have potential applications in drug development and medicinal chemistry. Further study and analysis of this compound are necessary to fully understand its potential uses and effects.

Upstream product

• 468741-50-6 C₂₅H₂₇ClN₆O₂ 
• 107-13-1 acrylonitrile 

Relevant articles and documents

Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one

A series of 3-[6-(4-substitued-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one were synthesized to modulate CYP3A4 inhibition and improve aqueous solubility of our prototypical compound BMS-536924 (1), while maintaining potent IGF-1R inhibitory activity. Structure-activity and structure-solubility studies led to the identification of BMS-577098 (27), which demonstrates oral in vivo efficacy in animal models. The improvement was achieved by replacing morpholine with more polar bio-isoster piperazine and modulating the basicity of distal nitrogen with appropriate substitutions.