469-77-2

Basic information

• Product Name: SPICULISPORIC ACID
• Synonyms: 4,5-DICARBOXY-4-PENTADECANOLIDE;4,5-DICARBOXY-GAMMA-PENTADECANOLACTONE;SPICULISPORIC ACID;4,5-Dicarboy-gamma-pentadecanolactone;Dicarboypentadecanolactone;4,5-DICARBOXY-GAMMA-PENTADECANOLACTONE 97+%;4,5-Dicarboxy-γ-pentadecanolactone;4,5-Dicarboxy-&gamma
• CAS NO: 469-77-2
• Molecular Formula: C17H28O6
• Molecular Weight: 328.4
• Product Categories: Heterocycles;Inhibitors
• Mol File: 469-77-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 145 °C
• Boiling Point: 549°Cat760mmHg
• Flash Point: 195.4°C
• Appearance: /
• Density: 1.163g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.13±0.20(Predicted)
• CAS DataBase Reference: SPICULISPORIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: SPICULISPORIC ACID(469-77-2)
• EPA Substance Registry System: SPICULISPORIC ACID(469-77-2)

Safety Data

• Hazardous Substances Data: 469-77-2(Hazardous Substances Data)

Usage

General Description

Spiculisporic acid is a natural product isolated from the marine-derived fungus Penicillium spiculisporum. It belongs to the class of fungal secondary metabolites known as spiroketals and exhibits potent antibacterial and antifungal activities. Spiculisporic acid has been shown to inhibit the growth of various pathogenic bacteria and fungi, making it a potentially valuable lead compound for the development of new antimicrobial drugs. It has also been found to display cytotoxicity against various cancer cell lines, indicating its potential as an anticancer agent. Overall, spiculisporic acid holds promise for its therapeutic applications in the treatment of infectious diseases and cancer.

Upstream product

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Relevant articles and documents

The first enantioselective organocatalytic Mukaiyama-Michael reaction: A direct method for the synthesis of enantioenriched γ-butenolide architecture

The first enantioselective organocatalytic Mukaiyama-Michael reaction using α,β-unsaturated aldehydes has been accomplished. The use of iminium catalysis has provided a new strategy for the enantioselective addition of 2-silyloxy furans to unsaturated aldehydes to generate a variety of butenolide systems, an important chiral synthon found among many natural isolates. The (2S,5S)-5-benzyl-2-tert-butyl-imidazolidinone amine catalyst has been found to mediate the conjugate addition of a wide variety of substituted and unsubstituted silyloxy furans to unsaturated aldehydes. A diverse range of aldehyde substrates can be accommodated in this new organocatalytic transformation. Application of this new asymmetric technology to the enantioselective total synthesis of spiculisporic acid and the corresponding 5-epi-spiculisporic acid analogue is also discusse. Copyright