4695-19-6

Basic information

• Product Name: 2-amino-5,5-dimethyl-1,3-thiazol-4-one
• Synonyms: 2-amino-5,5-dimethyl-1,3-thiazol-4-one;2-Amino-5,5-dimethyl-4(5H)-thiazolone;2-Imino-5,5-dimethyltetrahydrothiazol-4-one
• CAS NO: 4695-19-6
• Molecular Formula: C₅H₈N₂OS
• Molecular Weight: 0
• Mol File: 4695-19-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 237°Cat760mmHg
• Flash Point: 97.2°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 0.0458mmHg at 25°C
• Refractive Index: 1.648
• CAS DataBase Reference: 2-amino-5,5-dimethyl-1,3-thiazol-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5,5-dimethyl-1,3-thiazol-4-one(4695-19-6)
• EPA Substance Registry System: 2-amino-5,5-dimethyl-1,3-thiazol-4-one(4695-19-6)

Safety Data

• Hazardous Substances Data: 4695-19-6(Hazardous Substances Data)

Usage

Structure

Five-membered ring containing sulfur and nitrogen atoms

Uses

Organic synthesis, pharmaceutical research

Properties

Reactivity, ability to form complexes with metal ions

Biological activities

Antimicrobial, antihypertensive, anticonvulsant

Potential applications

Drug development, corrosion inhibition, fluorescence detection of metal ions

InChI:InChI=1/C5H8N2OS/c1-5(2)3(8)7-4(6)9-5/h1-2H3,(H2,6,7,8)

Upstream product

• 2052-01-9 2-bromo-2-methylpropionic acid 
• 17356-08-0 thiourea 
• 22421-97-2 methyl 2-chloroisobutyrate 
• 57-15-8 1,1,1-trichloro-2-methyl-2-propanol 
• 67-56-1 methanol 
• 600-00-0 ethyl 2-bromoisobutyrate 

Downstream Products

• 57-13-6 urea 
• 420-04-2 CYANAMID 
• 4695-31-2 2-mercapto-2-methylpropanoic acid 

Relevant articles and documents

Novel preparation method of 2-mercaptoisobutyric acid

The invention provides a novel preparation method of 2-mercaptoisobutyric acid. Raw materials used in the method comprise 2-ethyl bromoisobutyrate, thiourea, an alkali solution, a solvent, and a hydrolyzate. Compared with other synthetic methods, the method provided by the invention has the advantages of a high yield, high purity, cheap and easy-availability reagents, mild reaction conditions, a simple technological process and environmental friendliness.

The reactions of ethyl-, vinyl-, and ethynyl(trichloromethyl)carbinols with aqueous amd methanolic potassium hydroxide, thiourea, and cyanamide

The reactions of ethyl(trichloromethyl)carbinol, dimethyl(trichloromethyl)carbinol. (trichloromethyl)vinylcarbinol, ethynyl(trichloromethyl)carbinol, and 1,1,1-trichloro-3-nonyn-2-ol have been studied with the following reagents.Methanolic potassium hydroxide: α-methoxy acids are formed in 70 and 79 percent yields with the ethyl- and vinylcarbinols respectively.Double bond migration to the conjugated position was observed with the vinylcarbinol.Thiourea: substituted 2-imino-4-thiazolidinones are formed in 27 to 66 percent yield with the first three carbinols with double bond migration in the case of the vinylcarbinol.Cyanamide: the saturated carbinols were converted to substituted ethyl 2-imino-4-oxo-1-imidazolidinecarboximidates in 30 to 60 percent yield.Aqueous potassium hydroxide: α-chloro acids were formed from the ethyl- and vinylcarbinols in 23 and 24 percent yields respectively, again with double bond migration in the case of the vinylcarbinol.The results are discussed in terms of the known parallel reactions with phenyl(trichloromethyl)carbinol, and provide information which illustrates the usefulness and defines the limits of certain known synthetic reactions when applied to the alkyl, alkenyl, and alkynyl trichloromethylcarbinols.