4697-90-9Relevant articles and documents
Diastereoselectivity control of the radical carboazidation of substituted methylenecyclohexanes
Cren, Sylvaine,Schar, Pascal,Renaud, Philippe,Schenk, Kurt
supporting information; experimental part, p. 2942 - 2946 (2009/09/06)
A systematic study of the diastereoselectivity of the radical carboazidation of methylenecyclohexane derivatives is presented. Several substitution patterns leading to a high level of stereocontrol have been identified. Axial attack is the preferred reaction pathway for cyclohexyl radicals, and excellent stereoselectivities can be obtained by introducing an axial substitutent at position 2. In this case, a second equatorial substituent at position 2 may be tolerated without a large detrimental effect on the diastereoselectivity. Finally, a high level of equatorial attack is observed with a very bulky substituent at position 2.
Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency
Chen,Kozikowski,Wood,Reynolds,Ball,Pang
, p. 1634 - 1638 (2007/10/02)
The synthesis and chemical resolution of cis- and trans-fused 8a- phenyldecahydroquinolines 3 and 4 are described together with the affinity of the four optically pure compounds for the PCP recognition site of the NMDA receptor complex. These compounds we
