4701-54-6Relevant articles and documents
Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid
Salimova,Mamaev,Tret’yakova,Kukovinets,Mavzyutov,Shvets, K. Yu.,Parfenova
, p. 1411 - 1418 (2018)
3,11-Dihydroxy and 3,11-dioxo triterpenoids of the fusidane series reacted with acrylonitrile in 1,4-dioxane in the presence of alkali and phase-transfer catalyst to give mono- and bis(2-cyanoethoxy) and 2-cyanoethyl derivatives. The reaction with 3,11-dioxo analog afforded 2,2-disubstituted derivative as a result of addition of two cyanoethyl groups to the α-position with respect to the C3=O carbonyl group. The isolated compounds were screened for antibacterial and antifungal activities.
17S,20S-Methanofusidic acid, a new potent semi-synthetic fusidane antibiotic.
Duvold, Tore,Jorgensen, Anne,Andersen, Niels R,Henriksen, Anne S,Dahl Sorensen, Morten,Bjoerkling, Fredrik
, p. 3569 - 3572 (2007/10/03)
A novel fusidic acid type antibiotic having the side chain linked to the tetracyclic ring system via a spiro-cyclopropane system is described. 17S,20S-Methanofusidic acid is obtained by an efficient synthetic route including cyclopropanation of the Delta17(20) bond with attack solely from the least hindered alpha-face. The spiro-cyclopropane system orients the side chain into a bioactive conformational space. The new 17S,20S-methanofusidic acid exerts antibacterial activity against several Gram-positive species with potency essentially equal to natural fusidic acid.