4703-96-2

Basic information

• Product Name: (5E)-5-(furan-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
• Synonyms: (5E)-5-(2-Furylmethylene)-2-thioxo-1,3-thiazolidin-4-one; 4-Thiazolidinone, 5-(2-furanylmethylene)-2-thioxo-, (5E)-; 5-(2-Furylmethylene)-2-thioxo-1,3-thiazolidin-4-one
• CAS NO: 4703-96-2
• Molecular Formula: C₈H₅NO₂S₂
• Molecular Weight: 211.2608
• Mol File: 4703-96-2.mol
• Article Data: 10

Chemical Properties

• Density: 1.54g/cm³
• Refractive Index: 1.725
• CAS DataBase Reference: (5E)-5-(furan-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5E)-5-(furan-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one(4703-96-2)
• EPA Substance Registry System: (5E)-5-(furan-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one(4703-96-2)

Safety Data

• Hazardous Substances Data: 4703-96-2(Hazardous Substances Data)

Usage

Description

(5E)-5-(furan-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one is a thiazolidine derivative featuring a furan ring, with a molecular formula of C8H5NO2S2 and a molecular weight of 215.26 g/mol. (5E)-5-(furan-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one holds potential pharmaceutical applications due to its unique structural characteristics and biological activities.

Uses

Used in Pharmaceutical Industry:
(5E)-5-(furan-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one is used as a compound with potential pharmaceutical applications for its structural characteristics and biological activities. It is being studied for its antibacterial, antifungal, antiviral, and anticancer properties, as well as its potential role in treating diabetes and inflammation.
Used in Antimicrobial Applications:
In the field of antimicrobials, (5E)-5-(furan-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one is used as an active agent for its antibacterial, antifungal, and antiviral activities, which can contribute to the development of new treatments for various infections.
Used in Anticancer Applications:
Within the oncology sector, (5E)-5-(furan-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one is used as a compound with potential anticancer properties, which may aid in the development of novel therapeutic agents against cancer.
Used in Treatment of Diabetes and Inflammation:
(5E)-5-(furan-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one is also used as a compound with potential applications in the treatment of diabetes and inflammation, due to its biological activities that may help in managing these conditions.

Upstream product

• 98-01-1 furfural 
• 141-84-4 2-thioxo-4-thiazolidinone 

Downstream Products

• 4066-13-1 3-furan-2-yl-2-thioxo-propionic acid 
• 37530-61-3 5-furfurylidene-3-phenyl-2-thioxo-thiazolidin-4-one 
• 55927-33-8 3-(2-furyl)-2-sulfanylpropenoic acid 

Relevant articles and documents

Compound for specifically inhibiting plasma membrane H-ATPase (Adenosine Triphosphatase) in plant as well as preparation method and application thereof

The invention relates to a compound capable of specifically inhibiting a plasma membrane H-ATPase (Adenosine Triphosphatase) in a plant. The structural general formula of the compound is as shown in the following descriptions. The compound provided by the invention has a specific inhibition effect on the plasma membrane H-ATPase, and has obvious inhibition effects on pathogenic fungi in an animal and the plant.

Urea/thiourea catalyzed, solvent-free synthesis of 5-arylidenethiazolidine- 2,4-diones and 5-arylidene-2-thioxothiazolidin-4-ones

An efficient and organo-catalyzed method has been developed for the synthesis of 5-arylidenethiazolidine-2,4-diones and 5-arylidene-2- thioxothiazolidin-4-ones via Knoevenagel condensation of arylaldehydes 1 and 2,4-thiazolidinedione 2a/2-thioxothiazolidin-4-one 2b under mild conditions. Urea-adduct 4 and azomethine 5 also afford arylidene-products 3 by reacting with 2a-b via addition-elimination reaction. This protocol has the features of use of inexpensive, ecofriendly readily available, effective catalyst system viz. urea/thiourea, avoidance of volatile solvents, excellent yield and simple work-up procedure.

A solvent-free protocol for the green synthesis of arylalkylidene rhodanines in a task-specific ionic liquid

2-Hydroxyethylammonium formate acts as a task-specific ionic liquid (TSIL) for the Knoevenagel condensation of carbonyl compounds with rhodanine to afford arylalkylidene rhodanines under solvent-free conditions and in good-to-excellent yields. Additionally, compared with those in organic solvents, the yields obtained in the presence of our ionic liquid (IL) were significantly increased. The detailed mechanism of the catalytic effect of TSIL is also reported for the first time.