470688-50-7Relevant articles and documents
Structure-based design of peptidomimetic antagonists of p56lck SH2 domain
Hobbs, Christopher J.,Bit, Rino A.,Cansfield, Andrew D.,Harris, Bill,Hill, Christopher H.,Hilyard, Katherine L.,Kilford, Ian R.,Kitas, Eric,Kroehn, Antonin,Lovell, Peter,Pole, David,Rugman, Paul,Sherborne, Brad S.,Smith, Ian E.D.,Vesey, David R.,Walmsley, D. Lee,Whittaker, David,Williams, Glyn,Wilson, Fiona,Banner, David,Surgenor, Allan,Borkakoti, Neera
, p. 1365 - 1369 (2007/10/03)
Starting from the tetrapeptide Ac-pYEEI-NHMe and using a structure-based approach, we have designed and synthesised a peptidomimetic ligand for p56lck SH2 domain containing a conformationally restricted replacement for the two glutamate residue