471-56-7Relevant articles and documents
Hemisynthetic secofriedelane triterpenes with inhibitory activity against the growth of human tumor cell lines in vitro
Moiteiro, Cristina,Manta, Cesar,Justino, Fatima,Tavares, Regina,Curto, Maria Joao M.,Pedro, Madalena,Nascimento, Maria Sao Jose,Pinto, Madalena
, p. 1193 - 1196 (2004)
Seco acids 7 and 9 and hydroxylated analogues 5 and 6 derived from friedelane triterpenes were synthesized stereoselectively in high yields. Compounds 5-9 were evaluated for their ability to inhibit in vitro the growth of three human tumor cell lines, MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer). Only compounds 7 and 9 were found to possess significant growth inhibitory effects, exhibiting GI 50 values that range from 24.6 to 32.8 μM and 10.9 to 17.6 μM, respectively.
Basic Autoxidation of Friedelin
Nishihama, Tadaaki,Takahashi, Takeyoshi
, p. 2117 - 2126 (2007/10/02)
Base-catalized autoxidation of a triterpene ketone, friedelin, in the presence of potassium t-butoxide gave four products, and their structures and formation mechanism were investigated.The common intermediate to these compounds was suggested to be 4-hydroperoxyfriedelan-3-one, not friedelane-2,3-dione. 3-Oxafriedel-1-ene-2-carboxylic acid was a dehydration product of the main product, 2-hydroxy-3-oxafriedelane-2-carboxylic acid.