4717-38-8Relevant articles and documents
An efficient synthesis of 17-epi-ethynylestradiol
Ewers, Christian L. J.,Harre, Michael,Mohr, Joerg,Nickisch, Klaus,Tilstam, Ulf
, p. 4277 - 4282 (1998)
An efficient synthesis has been developed yielding 17-epi- ethynylestradiol 2 in an overall yield of 17 %. The key derivatives 7a-c were prepared from estrone in four steps. Subsequently epoxides 7a,c were efficiently transformed into 2 via Takano's method.
Compound
-
, (2008/06/13)
Disclosed and claimed are compounds suitable for use as an inhibitor of oestrone sulphatase in a subject in need thereof, as well as compositions containing such compounds and methods for using such compounds. Such compounds can be a sulphamate compound that has the Formula (X) and wherein X is a sulphamate group, and Y is CH2 and optionally any other H attached directly to the ring system is substituted by another group
17-Aryl linker derivatised estrogen 3-sulphamates as inhibitors of steroid sulphatase
-
, (2008/06/13)
There is provided a compound comprising a steroidal ring system and a group R1 selected from any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula —L—R3, wherein L is an optional linker group and R3 is an aromatic hydrocarbyl group.
