4724-62-3Relevant articles and documents
Formal synthesis of aspidospermidine via the intramolecular cascade transannular cyclization
Huang, Jiu-Zhong,Jie, Xiao-Ke,Wei, Kun,Zhang, Hongbin,Wang, Min-Cai,Yang, Yu-Rong
, p. 1303 - 1306 (2013)
A formal synthesis of aspidospermidine is reported through a novel preparation of Stork's penultimate tricyclic ketone intermediate. The key steps of the synthesis consist of an intramolecular cascade transannular cyclization, triggered by the removal of Boc group, which simultaneously forms the C, D, and E rings of aspidospermidine and conveniently setting up the quaternary stereocenter via decarboxylative alkylation reaction of the β-keto ester. Georg Thieme Verlag Stuttgart. New York.
Total Synthesis of (-)-Rhazinilam and Formal Synthesis of (+)-Eburenine and (+)-Aspidospermidine: Asymmetric Cu-Catalyzed Propargylic Substitution
Shemet, Andrej,Carreira, Erick M.
, p. 5529 - 5532 (2017/10/25)
A total synthesis of (-)-rhazinilam and formal syntheses of (+)-eburenine and (+)-aspidospermidine that rely on a copper(I)-catalyzed asymmetric propargylic substitution as the key step are reported. A salient feature of the reaction is the asymmetric con
Synthesis of biologically active natural products by [3?+?2] cycloaddition of non-stabilized azomethine ylides (AMY): Concepts and realizations
Pandey, Ganesh,Dey, Debasis,Tiwari, Sandip Kumar
, p. 699 - 705 (2017/03/31)
Non-stabilized azomethine ylides (AMY) which are represented as a zwitterionic form of a C[sbnd]N[sbnd]C unit having four electrons in three parallel atomic π orbitals perpendicular to the plane of the dipole, undergoes 1,3-dipolar cycloaddition to produc