473-41-6 Usage
Description
Tolbutamide sodium, also known as 1-butyl-3-(p-tolylsulfonyl)urea monosodium salt (Orinase Diagnostic), is a white, crystalline powder. It is freely soluble in water, soluble in alcohol and chloroform, and very slightly soluble in ether.
Uses
Used in Pharmaceutical Industry:
Tolbutamide sodium is used as an antidiabetic drug for the treatment of type 2 diabetes mellitus. It works by increasing the secretion of insulin from the pancreas, thereby lowering blood glucose levels.
Used in Diagnostic Tests:
Tolbutamide sodium is used as a diagnostic aid in the assessment of endogenous insulin secretion and in the diagnosis of insulinomas. It helps in stimulating insulin release, which can be measured to evaluate the function of the pancreas and detect any abnormalities.
Used in Research:
Tolbutamide sodium is used as a research tool in the study of insulin secretion, glucose metabolism, and the development of new antidiabetic drugs. It provides valuable insights into the mechanisms of insulin action and the pathophysiology of diabetes.
Clinical Use
This water-soluble salt of tolbutamide is used intravenouslyfor the diagnosis of mild diabetes mellitus and offunctioning pancreatic islet cell adenomas. The sterile drypowder is dissolved in sterile water for injection to make aclear solution, which then should be administered within1 hour. The main route of breakdown is to butylamine andsodium p-toluene sulfonamide.
Check Digit Verification of cas no
The CAS Registry Mumber 473-41-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 3 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 473-41:
(5*4)+(4*7)+(3*3)+(2*4)+(1*1)=66
66 % 10 = 6
So 473-41-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
