473552-31-7

Basic information

• Product Name: 1,2-Ethanediol, 1-[4-(phenylmethoxy)phenyl]-, 2-(4-methylbenzenesulfonate), (1R)-
• CAS NO: 473552-31-7
• Molecular Formula: C22H22O5S
• Molecular Weight: 398.48
• Mol File: 473552-31-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-Ethanediol, 1-[4-(phenylmethoxy)phenyl]-, 2-(4-methylbenzenesulfonate), (1R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Ethanediol, 1-[4-(phenylmethoxy)phenyl]-, 2-(4-methylbenzenesulfonate), (1R)-(473552-31-7)
• EPA Substance Registry System: 1,2-Ethanediol, 1-[4-(phenylmethoxy)phenyl]-, 2-(4-methylbenzenesulfonate), (1R)-(473552-31-7)

Safety Data

• Hazardous Substances Data: 473552-31-7(Hazardous Substances Data)

Upstream product

• 10493-52-4 1-(4-benzyloxyphenyl)-2-(p-tolylsulfonyloxy)ethanone 

Downstream Products

• 63365-60-6 (R)-1-(p-benzyloxyphenyl)-2-[2-(3,4-dimethoxyphenyl)ethylamino]ethanol 
• 473552-26-0 (R)-(-)-2-amino-1-(p-benzyloxyphenyl)ethanol 
• 876-04-0 (R)-octopamine 
• 473552-22-6 (R)-(-)-2-azido-1-(4-benzyloxyphenyl)-1-ethanol 

Relevant articles and documents

Asymmetric transfer hydrogenation of 2-tosyloxy-1-(4-hydroxyphenyl)ethanone derivatives: synthesis of (R)-tembamide, (R)-aegeline, (R)-octopamine, and (R)-denopamine

Catalytic transfer hydrogenation of 2-tosyloxy-1-(4-hydroxyphenyl)ethanone derivatives leads to efficient synthesis of β-adrenergic agonists, (R)-tembamide, (R)-aegeline, (R)-octopamine, and (R)-denopamine.

METHOD FOR THE PREPARATION OF OPTICALLY ACTIVE 2-SULFONYLOXY-1-PHENYLETHANOL DERIVATIVES

Optically active 2-sulfonyloxy-1-phenylethanol derivative of formula (II) can be prepared easily and selectively by the method of the present invention using an asymmetric reduction of an α-sulfonyloxy acetophenone compound with a rhodium catalyst having petamethylcyclopentadienyl group and a hydrogen donor, and the compound of formula (II) obtained in the inventive method exhibits a higher e.e. (enantiomer excess) value than that of the products in the conventional methods.