473827-99-5Relevant articles and documents
Allosteric Interaction of Metal Ions with Saccharides in a Crowned Diboronic Acid
Deng, Gang,James, Tony D.,Shinkai, Seiji
, p. 4567 - 4572 (1994)
A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are succesfully coupled in an allosteric system.The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD).Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity.This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.