473910-22-4

Basic information

• Product Name: [9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-carbamic acid 2-nitro-benzyl ester
• Synonyms: [9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-carbamic acid 2-nitro-benzyl ester
• CAS NO: 473910-22-4
• Molecular Weight: 446.376
• Mol File: 473910-22-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-carbamic acid 2-nitro-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-carbamic acid 2-nitro-benzyl ester(473910-22-4)
• EPA Substance Registry System: [9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-carbamic acid 2-nitro-benzyl ester(473910-22-4)

Safety Data

• Hazardous Substances Data: 473910-22-4(Hazardous Substances Data)

Upstream product

• 612-25-9 2-Nitrobenzyl alcohol 

Downstream Products

• 58-61-7 adenosine 

Relevant articles and documents

Photolabile groups for exocyclic amino and O6/N-1 lactam protection in oligonucleotide synthesis

The use of o-nitrobenzyloxycarbonyl (nCbz) for direct protection of exocyclic amino function of nucleosides viz. adenosine, cytidine and deoxyguanosine using o-nitrobenzyl-p-nitrophenyl carbonate as a reagent and O6-derivatization of deoxyguanosine with o-nitrobenzyl (nBzl) using o-nitrobenzyldiazomethane as a reagent is being reported. Both these protected groups could be cleaved by irradiation at 354nm to yield valuable building blocks for oligonucleotide synthesis.