473923-97-6

Basic information

• Product Name: 3-chloro-5-hydroxy-benzonitrile
• Synonyms: 3-chloro-5-hydroxy-benzonitrile;3-Chloro-5-cyanophenol;3-chloro-5-hidroxybenzonitrile;3-chloro-5-hydroxyphenyl-carbonitrile;EOS-61114
• CAS NO: 473923-97-6
• Molecular Formula: C₇H₄ClNO
• Molecular Weight: 153.57
• EINECS: 1312995-182-4
• Product Categories: Phenyls & Phenyl-He
• Mol File: 473923-97-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 168.0 to 172.0 °C
• Boiling Point: 265.405 °C at 760 mmHg
• Flash Point: 114.313 °C
• Appearance: /
• Density: 1.415g/cm3
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 7.62±0.10(Predicted)
• CAS DataBase Reference: 3-chloro-5-hydroxy-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-5-hydroxy-benzonitrile(473923-97-6)
• EPA Substance Registry System: 3-chloro-5-hydroxy-benzonitrile(473923-97-6)

Safety Data

• Hazardous Substances Data: 473923-97-6(Hazardous Substances Data)

Usage

Chemical Properties

white powder

InChI:InChI=1/C7H4ClNO/c8-6-1-5(4-9)2-7(10)3-6/h1-3,10H

Upstream product

• 473923-96-5 3-chloro-5-methoxybenzonitrile 
• 1213790-87-4 3-chloro-5-((4-methoxybenzyl)oxy)benzonitrile 
• 6575-00-4 3,5-dichlorobenzonitrile 
• 766-84-7 3-chloro-benzonitrile 

Downstream Products

• 473920-64-8 3-[(3, 5-dimethyl-1H-pyrazol-4-yl)oxy]-5-chlorobenzonitrile 
• 473923-68-1 3-(1-acetyl-2-oxopropoxy)-5-chlorobenzonitrile 
• 867366-95-8 C₁₄H₆BrClFNO₂ 
• 770719-09-0 3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile 
• 770719-10-3 [3-(3-chloro-5-cyanophenoxy)-2-fluoro-4-nitrophenyl]acetic acid ethyl ester 
• 1068604-80-7 C₁₄H₈ClFN₂O₃ 
• 1003605-23-9 C₁₃H₆ClFN₂O₃ 
• 1155847-25-8 3-chloro-5-[(3-chloro-2,5,6-trifluoropyridin-4-yl)oxy]benzonitrile 
• 1155847-15-6 3-chloro-5-[(2,6-difluoropyridin-4-yl)oxy]benzonitrile 
• 1155846-91-5 3-chloro-5-[(5-chloro-3,6-difluoropyridin-2-yl)oxy]benzonitrile 
• 1210835-26-9 C₁₃H₈ClN₃O₄ 
• 1210835-14-5 C₁₉H₁₂ClN₃O₄ 
• 1210835-59-8 3-chloro-5-(2,3,6-trifluoropyridin-4-yloxy)benzonitrile 
• 1210835-92-9 C₁₄H₉BrClN₃O₄ 

Relevant articles and documents

Iridium-Catalyzed Silylation of C-H Bonds in Unactivated Arenes: A Sterically Encumbered Phenanthroline Ligand Accelerates Catalysis

We report a new system for the silylation of aryl C-H bonds. The combination of [Ir(cod)(OMe)]2 and 2,9-Me2-phenanthroline (2,9-Me2-phen) catalyzes the silylation of arenes at lower temperatures and with faster rates than

HETEROCYCLIC ANTIVIRAL COMPOUNDS

Compounds of formula I, wherein R1, R2, R3, X1, X2 and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.