473988-53-3

Basic information

• Product Name: (6R,7R)-2-(allyloxy)carbonyl-7-phenoxyacetamido-3-cephem-3-methyl 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazin-8-carboxylate
• Synonyms: (6R,7R)-2-(allyloxy)carbonyl-7-phenoxyacetamido-3-cephem-3-methyl 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazin-8-carboxylate
• CAS NO: 473988-53-3
• Molecular Weight: 581.566
• Mol File: 473988-53-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6R,7R)-2-(allyloxy)carbonyl-7-phenoxyacetamido-3-cephem-3-methyl 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazin-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (6R,7R)-2-(allyloxy)carbonyl-7-phenoxyacetamido-3-cephem-3-methyl 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazin-8-carboxylate(473988-53-3)
• EPA Substance Registry System: (6R,7R)-2-(allyloxy)carbonyl-7-phenoxyacetamido-3-cephem-3-methyl 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazin-8-carboxylate(473988-53-3)

Safety Data

• Hazardous Substances Data: 473988-53-3(Hazardous Substances Data)

Upstream product

• 63554-76-7 (6R,7R)-3-Acetoxymethyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 
• 85622-93-1 temozolomide 
• 10390-44-0 (6R)-3-acetoxymethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 113942-30-6 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrahydro-8-carboxylic acid 
• 473988-48-6 allyl 3-hydroxymethyl-7-phenoxyacetamido-3-cephem-2-carboxylate 

Relevant articles and documents

Synthesis and antibacterial activity of dual-action agents of a β-lactam antibiotic with cytotoxic agent mitozolomide or temozolomide

Dual-action agents 5a-f and 12a-f, a β-lactam antibiotic combined with a cytotoxic agent, mitozolomide (Meto) or temozolomide (Temo), were synthesised. The antibacterial activity (MICs) of the dual-action agents has been determined against a panel of bacteria including several β-lactamase producing strains. The tests showed 5a-f active against the non-β-lactamase producing methicillin sensitive Staphylococcus aureus (MSSA) strains, however, little synergistic effect between the β-lactam and the cytotoxic agent was observed. 12a-f demonstrated some synergistic effect against bacteria. 12a, in particular, is active against ampicillin resistant (β-lactamase-producing) strains of Serratia marcescens.